5-HT (5-hydroxytryptamine, serotonin) is one of the most versatile neurotransmitters. It signals in part through 5-HT3 receptors which belong to the super family of ligand-gated ion channels.
5-hydroxytryptamine type 3 (5-HT3) receptors are cation-selective Cys-loop receptors expressed in the central and peripheral nervous systems where they mediate fast excitatory neurotransmission2. Five receptor subunits have been identified thus far (5-HT3A to 5-HT3E) with 5-HT3A and 5-HT3B receptors being the best characterized among the different types. To form a functional receptor, five subunits assemble around a pore permeable to Na+, K+, and Ca2+ ions. The presence of one or more 5-HT3A receptor subunits is necessary and essential3. Each 5-HT3 receptor subunit has a large extracellular domain critical for ligand binding, four transmembrane domains important for pore formation, and an intracellular domain responsible for activity modulation, receptor trafficking and sorting2.
5-HT3 receptors have become important therapeutic targets for irritable bowel syndrome (IBS), side effects resulting from chemotherapeutic treatment, schizophrenia and bipolar disorder1,4.
Alomone Labs offers an extensive 5-HT3 receptor reagent portfolio. Our product range includes highly specific antibodies to the receptors, which enable detection of 5-HT3 receptors in western blot analysis and various immunostaining protocols.
We also offer a large array of pharmacological reagents:
- Highly pure products
- Negligible lot to lot variability
- All lots biologically tested
- Large size range available
- Lyophilized and shipped at room temperature
5-HT3 receptor Explorer Kits are Budget-Friendly priced screening packages. Each Explorer Kit contains a set of antibodies or a group of pharmacological reagents targeting 5-HT3 receptors.