Free shipping starts now, no minimum!


BDNF – Second Best?

Brain Derived Neurotrophic Factor (BDNF) is the second best characterized neurotrophin (following NGF) and acts as a key contributor to …

Continue reading

Role of Voltage-Gated K+ Channels in the Pathophysiology of Spinal Cord Injury

Spinal cord injury (SCI) is a devastating condition afflicting over 13,000 people annually in North America and is an important cause of mortality and neurological morbidity1.

Although early pharmacological intervention after SCI with methylprednisolone2,3 or GM-1 ganglioside4 results in modest neurological improvement, the overall impact of these treatments remains minimal. Therefore, novel therapeutic approaches are required to improve the neurological outcome of these patients.

Continue reading

Muscarinic Receptors

Acetylcholine, the major neurotransmitter in the central and the peripheral nervous system, can act through two kinds of receptors1: ionotropic …

Continue reading

The Ionotropic GABAA Receptor

GABA (g-aminobutiric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the nervous system.1

The GABA transmitter interacts with two major types of receptors: ionotropic GABAA (GABAAR) and the metabotropic GABAB receptors. The GABAAR belong to the ligand-gated ion channel superfamily.2

Continue reading