Modulator

Issue No. 20

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Voltage Dependent Ca2+ (CaV) Channels

In many physiological systems, voltage dependent Ca2+ (CaV) channels are the molecular link between cellular membrane potential and intracellular Ca2+ signaling. As such, CaV channels are drug targets for several cardiovascular and neuronal conditions and the role they play in other, non-excitable …

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Targeting Ion Channels in Living Cells

During the last few years there has been an increased focus on ion channel-related research in tissues and cells other than the nervous system. Every cell in the body expresses several kinds of ion channels that perform various (and sometimes essential) physiological functions. This broadening of …

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Ca2+-Dependent K+ (KCa) Channels: At the Crossroads of Cell Metabolism

K+ channels are the largest and most diverse superfamily of ion channels. They are ubiquitously expressed in both excitatory and non-excitatory cells where they play a role in an assortment of different physiological functions such as cell proliferation and apoptosis, neuro- and cardio-protection, …

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The Transient Receptor Potential (TRP) Ion Channels

TRP channels show diverse biophysical properties and gating mechanisms and were found to play an important role in sensory physiology, being involved in almost every sensory signal initiation from pain sensation to the five senses. A Remarkable Multifunctional Superfamily The TRP superfamily is …

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