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An Antagonist of 5-HT3 Channels

Cat #: A-205
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 395.41
    Purity: >98%
    Effective concentration 1-100 µM.
    Chemical name 3-(4-allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate.
    Molecular formula C20H21N5O4.
    CAS No.: 149685-89-2
    Activity 3-AQC is a potent and selective 5-HT3A receptor antagonist1.
    1. Monge, A. et al. (1993) J. Med. Chem. 36, 2745.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs 3-AQC blocks 5-HT3A channels expressed in HEK 293T cells. 
      Alomone Labs 3-AQC blocks 5-HT3A channels expressed in HEK 293T cells. 
      Currents were elicited by 10 µM 5-HT, delivered every 3 minutes. 3-AQC (#A-205) was applied 30 seconds before stimulation at 10 and 100 µM, as indicated, and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
    References - Scientific background
    1. Hannon, J. and Hoyer, D. (2008) Behav. Brain Res. 195, 198.
    2. Monge, A. et al. (1993) J. Med. Chem. 36, 2745.
    Scientific background

    Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.

    3-AQC is a potent and selective antagonist of the 5-HT3A channel. 3-AQC is a derivative of Piperazinyquinoxaline synthetically designed to be 100 times more potent in blocking Serotonin receptors than Tropisetron.

    Target 5-HT3A channel
    Last update: 25/07/2021

    3-AQC (#A-205) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Shipping and Ordering information