SDZ 205-557 hydrochloride

An Antagonist of 5-HT3 Channels and 5-HT4 Receptors
    Cat #: S-145
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 337.2
    Purity: >99%
    Effective concentration 100 nM - 10 µM.
    Structure
    • SDZ 205-557 hydrochloride
    Chemical name 2-(diethylamino)ethyl 4-amino-5-chloro-2-methoxybenzoate;hydrochloride.
    Molecular formula C14H22Cl2N2O3.
    CAS No.: 137196-67-9.
    Activity SDZ 205-557 hydrochloride is a 5-HT3 and 5-HT4 receptor antagonist1.
    References-Activity
    1. Eglen, R.M. et al. (1993) Br. J. Pharmacol. 108, 376.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 65 mg/ml in H2O. 100mg/ml in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • SDZ 205-557 hydrochloride
      Alomone Labs SDZ 205-557 hydrochloride blocks 5-HT3A receptors expressed in HEK 293T cells. 
      Currents were elicited by 10 µM 5-HT, delivered every 3 minutes. SDZ 205-557 hydrochloride (#S-145) was applied 30 seconds before stimulation at 1 and 10 µM, as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
    References - Scientific background
    1. Eglen, R.M. et al. (1993) Br. J. Pharmacol. 108, 376.
    2. Fayyaz, M. and Lackner, J.M. (2008) Ther. Clin. Risk Manag. 4, 41.
    3. McMahon, L.R. and Cunningham, K.A. (1999) J. Pharmacol. Exp. Ther. 291, 300.
    Scientific background

    SDZ 205-557 is a potent 5-HT3 and 5-HT4 receptor antagonist with a greater affinity for 5-HT4 receptor with a Ki value of 10.6 nM3. It lacks affinity for other 5-HT receptors. SDZ 205-557 is thus suggested to be used as a useful ligand to characterize and define the 5HT-4 receptor. SDZ 205-557 has the ability to cross the blood brain barrier and has a short duration of action that may complicate its use in vivo1,3.

    5-HT3 and 5HT4 are members of the serotonin-gated and G protein coupled receptor superfamily respectively. 5-HT3 receptors are expressed throughout the central and peripheral nervous systems. High levels of 5-HT4 receptors can be found in the olfactory system, striatum, hippocampus, and substantia nigra2,3.

    Target 5-HT3, 5HT4 receptors
    Last update: 24/01/2020

    SDZ 205-557 hydrochloride (#S-145) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Shipping and Ordering information