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Serotonin hydrochloride

Agonist of all 5-HT Receptors and Transporters

Cat #: S-165
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 212.7
    Purity: >98%
    Effective concentration 50 nM - 50 µM.
    Chemical name 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride.
    Molecular formula C10H13ClN2O.
    CAS No.: 153-98-0
    PubChem CID 160436
    Activity Serotonin is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo1.
    1. Barnes, N.M. et al. (1999) Neuropharmacology 38, 1083.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 150 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Serotonin hydrochloride activates 5-HT3A receptors expressed in HEK 293T cells. 
      Alomone Labs Serotonin hydrochloride activates 5-HT3A receptors expressed in HEK 293T cells. 
      5-HT3A receptor currents were elicited by 1 or 10 µM Serotonin hydrochloride (#S-165), as indicated. 0.1 µM failed to activate currents here.
    References - Scientific background
    1. Arreola, R. et al. (2015) J. Immunol. Res2015, 354957.
    2. Lin, S.H. et al. (2014) Clin. Psychopharmacol Neurosci. 12, 196.
    3. Gaffney, R.R. et al. (2015) Case. Rep. Gastroenterol. 9, 132.
    Scientific background

    Serotonin is the endogenous agonist of 5-HT receptors and the endogenous substrate for the synthesis of a number of molecules, such as melatonin, formyl­5­hydroxykynurenamine, and 5­hydroxyindoleacetic acid.

    Serotonin (5­HT), also known as 5­hydroxytryptamine is a monoamine derived from tryptophan. Primarily, serotonin can be found in the gastrointestinal tract, blood platelets, and the central nervous system (CNS)1. Only 2% of serotonin is present in the CNS where it plays an important role in the etiology of many mental disorders. 5-HT also plays an important role in regulating mood and social behavior, appetite, sleep, pain, bone density, tissue regeneration, platelet aggregation, gastrointestinal function, memory and sexual desire and function1,2. In addition, serotonin affects the immune, gastrointestinal and nervous systems in a paracrine, endocrine, and juxtacrine manner2.

    An extensive use or overdose of serotonergic drugs can lead to a rare life threatening syndrome called serotonin syndrome that includes mental status changes, neuromuscular abnormalities and autonomic hyperactivity3.

    Target 5-HT1, 5-HT2, 5-HT3 receptors
    Last update: 06/11/2022

    Serotonin hydrochloride (#S-165) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Shipping and Ordering information