- Peptide (C)KNKTEAFALEKFYR, corresponding to amino acid residues 355-368 of rat GlyRα3 (Accession P24524). 2nd intracellular loop.
- Western blot analysis of rat brain membranes:1. Anti-Glycine Receptor α3 Antibody (#AGR-003), (1:200).
2. Anti-Glycine Receptor α3 Antibody, preincubated with Glycine Receptor α3 Blocking Peptide (#BLP-GR003).
- Rat trigeminal ganglion sections (1:100) (Bae, J.Y. et al. (2016) Brain Struct. Funct. 221, 4601.).
- Becker, C.M. (1995) The Neuroscientist 1, 130.
- Gisselmann, G. et al. (2002) Eur. J. Neurosci. 16, 69.
- Nikolic, Z. et al. (1998) J. Biol. Chem. 273, 19708.
- Breitinger, H.G. et al. (2002) J.Neurochem. 83, 30.
Glycine is a major neurotransmitter in the mammalian central nervous system.1 The glycine receptor is a ligand gated Cl- channel, mediating synaptic inhibition in the spinal cord, retina and regions of the brain.2
The glycine receptor is a pentamer consisting of α and β subunits. To date there are four known α-subunit isoforms (α1-α4) encoded by different genes.2-4
In humans, two alternative splice variants of the glycine receptor α3 have been described: α3L and α3K, where the α3L splice variant bears an additional segment of 15 amino acids within the long cytoplasmic TM3-4 loop. These variants differ in their desensitization kinetics.3
Application key:
Species reactivity key:
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of the rat glycine receptor α3. Anti-Glycine Receptor α3 Antibody (#AGR-003) can be used in western blot and immunohistochemistry applications. It has been designed to recognize GlyRα3 from rat, mouse and human samples.
Applications
Citations
- Rat trigeminal ganglion sections (1:100).
Bae, J.Y. et al. (2016) Brain Struct. Funct. 221, 4601.
Specifications
Scientific Background
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