Every lot is tried & tested in a relevant biological assay.
Our Bioassay
- Scaloni, A. et al. (2000) FEBS Lett. 479, 156.
- Gurrola, G.B. et al. (1999) FASEB. J. 13, 953.
- Alomone Labs Ergtoxin-1 inhibits the current of KV11.1 (hErg) channels expressed in Xenopus oocytes.A. Representative time course of KV11.1 current inhibition by 50 nM Ergtoxin-1 (#STE-450), as indicated (green). B. Superimposed traces of KV11.1 current after application of control solution (black) and of 50 nM Ergtoxin-1 (green), taken from the recording in A. Membrane potential was held at -100 mV. Current was elicited every 10 sec by a 200 ms voltage step to +40 mV, followed by a 200 ms step to -40 mV (as shown below).
- Scaloni, A. et al. (2000) FEBS Lett. 479, 156.
- Gurrola, G.B. et al. (1999) FASEB. J. 13, 953.
Ergtoxin-1 was originally isolated from Centruroides noxius scorpion venom.
The peptide toxin specifically blocks KV11.1 (ERG) K+ channels in different tissues and across species1,2. Patch clamp recordings from cultured cell lines and cardiac myocytes showed specific blocking of ERG currents with an IC50 of 16 nM, and increased firing rate in neurons as well as cardiac action potential broadening1,2.
Ergtoxin-1 (#STE-450) is a highly pure, synthetic, and biologically active peptide toxin.
Applications
Citations
- HEK 293 cells stably transfected with HERG (whole cell patch clamp).
Milnes, J.T. et al. (2003) FEBS Lett. 547, 20.
Specifications
Scientific Background
Related Products
Antibodies
Pharmacological tools
Explorer kits & Research packs
Need Help With This Product?
Our reagent specialists are here to help you find the best product for your application. Please call or email us and we will be happy to help you find the right product for the job.
Call us at
+972 2587 2202 or Email Us