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Frescolat MGA

Menthone 1,2-glycerol ketal

An Activator of TRPM8 Channels

Cat #: F-165
Alternative Name Menthone 1,2-glycerol ketal
  • Bioassay Tested
  • Source Synthetic
    MW: 228.33
    Purity: >97%
    Effective concentration 0.1-10 µM.
    Chemical name (9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol.
    Molecular formula C13H24O3.
    CAS No.: 63187-91-7
    PubChem CID 162184
    Activity Frescolat MGA is a TRPM8 channel activator and cooling agent. It activates mouse TRPM8 channels with EC50 of 4.8 µM1.
    1. Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Store in a cool and dry place.
    Solubility Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
    Storage of solutions Up to three months at -20°C.
    Our bioassay
    • Alomone Labs Frescolat MGA activates TRPM8 channels expressed in HEK-293 cells.
      Alomone Labs Frescolat MGA activates TRPM8 channels expressed in HEK-293 cells.
      Dose response curve of the activation of TRPM8, shown as relative fluorescence plotted against increasing concentrations of Frescolat MGA (#F-165). EC50 was determined at 1.77 µM. Cells were loaded with Calcium-5 dye. Changes in intracellular Ca2+ following agonist application were detected as changes in 485 nm/525 nm fluorescence (RFU).
    References - Scientific background
    1. Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737.
    2. Tsumura, Met al. (2013) PLoS One  8, e82233.
    Scientific background

    Frescolat MGA is a synthetic compound that acts as a TRPM8 channel activator. Studies show that Frescolat MGA has the ability to activate mouse TRPM8 channels and to produce concentration-dependent increase in Ca2+ levels with an EC50 value of 4.8 µM1.

    TRPM8 channel is a member of the TRP channels superfamily. TRPM8 is Ca2+-permeable, nonselective cation channel that is activated by temperatures in the range of 8–28°C and by chemical agonists such as menthol and icilin. TRPM8 is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons and is up-regulated in prostate cancer and other malignancies1,2.

    Target TRPM8 channel
    Last update: 06/11/2022

    Frescolat MGA (#F-165) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use



    Scientific Background

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