Every lot is tried & tested in a relevant biological assay.
- Xiao, Y. and Liang, S. (2003) Eur. J. Pharmacol. 477, 1.
- Alomone Labs Hainantoxin-III inhibits NaV1.7 channels heterologously expressed in HEK293 cells.NaV1.7 currents were elicited by 30 ms voltage ramp from the holding potential of -100 mV to +60 mV, applied every 10 sec using whole-cell voltage clamp technique. A. Time course of NaV1.7 current amplitude changes before (black) and during (green) application of 0.5 µM Hainantoxin-III (#STH-120) indicated by the horizontal bar. B. Superimposed example current traces of NaV1.7 currents before (black) and during (green) 200 sec application of 0.5 µM Hainantoxin-III, as indicated.
Hainantoxin-III is a 33 amino acid peptidyl toxin isolated from the Haplopelma hainanum (Selenocosmia hainana, Chinese bird) tarantula spider1.
Hainantoxin-III strongly depresses the amplitude of TTX-sensitive Na+ currents with IC50 value of 1.1 nM1. It causes a hyperpolarizing shift of about 10 mV in the voltage midpoint of steady-state Na+ channel inactivation and significantly decreases the recovery rate from inactivation1.
The Haplopelma hainanum tarantula spider venom was recently found to be a source of various toxic components with different pharmacological properties2. 192 mature toxin sequences were identified by DNA sequencing technique. Hainantoxin-III was one of the toxins identified2.
Hainantoxin-III (#STH-120) is a highly pure, synthetic, and biologically active peptide toxin.