This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
Grissmer, S. et. al. (1994) Mol. Pharmacol. 45, 1227.
Alomone Labs Noxiustoxin inhibits KV1.3 channels heterologously expressed in Xenopus oocytes.Left: Time course of KV1.3 current amplitude in response to test pulses of 100 ms to 0 mV from a holding potential of -100 mV. 200 nM Noxiustoxin (#STN-340) was perfused at the period marked by the horizontal bar. Right: Traces of KV1.3 currents before (red) and during (black) application of Noxiustoxin.
- Possani, L.D. et. al. (1982) Carlsberg Res. Commun. 47, 285.
- Grissmer, S. et. al. (1994) Mol. Pharmacol. 45, 1227.
- Mullmann, T.J. et. al. (2001) Biochemistry 40, 10987.
- Martinez, F. et. al. (1996) Toxicon 34, 1413.
- Stiges, M. et. al. (1986) J. Neurosci. 6, 1570.
- Drakopoulou, E. et. al. (1995) Biochem. Biophys. Res. Commun. 213, 901.
Noxiustoxin was originally isolated from the venom of the scorpion Centruroides noxius Hoffmann1 and was shown to interact and inhibit KV1.2 and KV1.3 K+ channels.2 The toxin blocks KV1.3 (recorded using patch clamp in Jurkat cells) with Kd of 6 nM.3 It was shown to bind synaptosomal membranes4 and to increase transmitter release.5 In addition, it was shown to block K+ channels in lymphocytes.6
Noxiustoxin (#STN-340) is a highly pure, synthetic, and biologically active peptide toxin.