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- Lazarovici, P. et al. (1986) J. Biol. Chem. 261, 16704.
- Adermann, K. et al. (1998) FEBS Lett. 435, 173.
- Abu-Raya, S. et al. (1998) J. Pharmacol. Exp. Ther. 287, 889.
- Bloch-Shilderman, E. et al. (2002) J. Pharmacol. Exp. Ther. 301, 953.
- The activity of this lot was tested to confirm its ability to stimulate release of catecholamines from PC12 cells according to Lazarovici, P. et al.2.
- Lazarovici, P. et al.(1986) J. Biol. Chem. 261, 16704.
- Lazarovici, P. et al.(1992) J. Pharmacol. Exp. Ther. 263, 1317.
- Shai, Y. (1994) Toxicology. 87, 109.
Pardaxin is a 33 amino acid peptidyl toxin, produced by the Red Sea Moses sole fish Pardachirus marmoratus. Pardaxin is acidic, amphipathic, and hydrophobic that forms voltage-dependent pore channels in liposomes and planar lipid bilayers and living cells2.
The toxin exhibits a neurotoxic, excitatory activity toward neurons at subcytotoxic concentrations by both Ca2+-dependent and Ca2+-independent mechanisms. Pardaxin also causes hemolysis, reduction of blood pressure, cell death by necrosis, and is lethal to rats at higher concentrations3.
Pardaxin (#P-300) is a highly pure, natural, and biologically active peptide toxin.
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