This product is freeze dried. All water molecules have been removed.
The activity of this product has been verified and approved by our professional team.
This lyophilized product is shipped at room temperature. Please see its certificate of analysis for further storage instructions.
This vial contains 100% net peptide content.
Do not shake or vortex.
- Fohlman, J. et al. (1976) Eur. J. Biochem 68, 457.
- Lind, P. and Eaker, D. (1982) Eur. J. Biochem. 124, 441.
- Cull-Candy, S. et al. (1976) Neuroscience 1, 175.
- Kirkpatrick, L.L. et al. (2000) J. Biol. Chem. 275, 17786.
- Lambeau, G. et al. (1989) J. Biol. Chem. 264, 11503.
- Bonanomi, D. et al. (2005) Mol. Pharmacol. 67, 1901.
- Dreyer, F. and Penner, R. (1987) J. Physiol. 386, 455.
Taipoxin is a lethal neurotoxin protein isolated from the venom of the Australian taipan Oxyuranus s. scutellatus (LD50= 2 µg/kg in mouse). Taipoxin is a non-covalent ternary glycoprotein which is completely dissociated at low pH or high ionic strength. One of the subunits has Phospholipase A2 activity1,2.
Intoxicated animals die of asphyxia caused by a complete inhibition of neurotransmitter release and neuromuscular junction blockage of the respiratory muscles. In the central nervous system taipoxin blocks synaptic vesicle recycling by inhibiting the neuronal uptake pathway through the interaction with neuronal Pentraxin system components during synapse formation and remodeling1,3-5.
In neuronal cultures, Taipoxin facilitates Ca2+-dependent synaptic vesicle exocytosis and causes a complete depletion of stored neurotransmitter, resulting in synaptic transmission blockage. Taipoxin, at nanomolar range, causes swelling of nerve terminus and redistributon of synaptic vesicle proteins7.
Taipoxin (#T-460) is a highly pure, natural, and biologically active peptide toxin.