QX-222 chloride

A Blocker of NaChannels
Cat #: Q-200
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 261
    Purity: >98%
    Effective concentration 0.5-10 mM.
    Chemical name 2-[(2,6-Dimethylphenyl)amino]-N,N,N-trimethyl-2-oxoetha niminium chloride.
    Molecular formula C13H21N2OCl.
    CAS No.: 21236-55-5.
    Activity QX-222 chloride blocks NaV currents1 and also inhibits nicotinic ACh receptor channels2.
    Shipping and storage Lyophilized powder can be stored intact at room temperature four years.
    Solubility Water. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or six months at -20°C.
    Protect from light. Hygroscopic.
      • Alomone Labs QX-222 chloride inhibits native NaV channels in ND7-23 cells.
        Inhibition of NaV currents by applying extracellularly 10 mM QX-222 chloride (#Q-200) using whole cell patch clamp recordings. Currents were elicited from a holding potential of -100 mV and test pulses of 40 ms to -10 mV were delivered every 10 sec. Superimposed traces show the response before (black) and during (orange) application of QX-222 chloride.
    Note The net molecular weight of QX-222 chloride is 256.5 Da. According to elemental analysis, the molecule contains ¼ mol H2O.
      • QX-222 is a quarternary derivative of the local anesthetic Lidocaine. It was shown to block NaV currents and channels in a use-dependent manner.1 The blocking mechanism involves an intracellular binding site, but some NaV channels facilitate the passage of QX-222 via the open channel.2 In addition it was shown to inhibit nicotinic ACh receptor channels.3
    Target Various NaV Na+ channels
    Last update: 03/03/2019

    QX-222 chloride (#Q-200) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use