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- Romey, G. et al. (1976) Proc. Natl. Acad. U.S.A. 73, 4055.
- Tesseraux, I. et al. (1987) Naunyn Schmiedebergs Arch. Pharmacol. 336, 232.
- Nishio, M. et al. (1991) Br. J. Pharmacol. 104, 504.
- Cannon, S.C. and Corey, D.P. (1993) J. Physiol. 466, 501.
- Hoey, A. et al. (1994) Pharmacol. Toxicol. 75, 356.
- Chahine, M. et al. (1996) J. Membr. Biol. 152, 39.
- Fletcher, J.E. et al. (1999) Anesthisiology 90, 1294.
- Brand, S. et al. (2000) Eur. J. Neurosci. 12, 2387.
- Ravens, U. (1976) Naunyn Schmiedebergs Arch. Pharmacol. 296, 73.
- Alomone Labs ATX-II enhances hNaV1.5 currents in stably transfected HEK cells.hNaV1.5 currents were elicited by a 50 ms voltage step from the holding potential of -100 mV to -20 mV, applied every 20 sec, using whole-cell voltage clamp technique (bath solution contains TEA and pipette solution contains CsF). A. Time course, showing the effect of 0.05 nM, 0.5 nM, 5 nM and 50 nM ATX-II (#STA-700) on the current area, indicating a dose-dependent slowing of the hNaV1.5 inactivation. B. Superimposed traces of hNaV1.5 currents under control conditions and after 4-6 min perfusion with 0.05 nM, 0.5 nM, 5 nM and 50 nM ATX-II, as indicated.
- Romey, G. et al. (1976) Proc Natl. Acad. Sci. U.S.A. 73, 4055.
- Tesseraux, I. et al. (1987) Naunyn Schmiedebergs Arch. Pharmacol. 336, 232.
- Nishio, M. et al. (1991) Br. J. Pharmacol. 104, 504.
- Cannon, S.C. and Corey D.P. (1993) J. Physiol. 466, 501.
- Hoey, A. et al. (1994) Pharmacol. Toxicol. 75, 356.
- Chahine, M. et al. (1996) J. Membr. Biol. 152, 39.
- Fletcher, J.E. et al. (1999) Anesthesiology 90, 1294.
- Brand, S. et al. (2000) Eur. J. Neurosci. 12, 2387.
- Ravens, U. (1976) Naunyn-Schmiedeberg’s Arch. Pharmacol. 296, 73.
ATX-II is a 47 amino acid peptidyl toxin, originally isolated from Anemonia sulcata sea anemone venom. It is a potent neurotoxin, which modulates voltage-gated Na+ channel gating kinetics by delaying its inactivation and prolonging the action potential of excitable membranes.
ATX-II has been used as a powerful activator of TTX-sensitive and -insensitive Na+ channels in various excitable tissue and cell types (at concentration range of 10-100 nM).1-9
Effects of ATX-II on rabbit cardiomyocytes.Electrical stimulation-induced changes in [Na+]i in the absence (control) and presence of 5 nM ATX-II (#STA-700).Adapted from Kornyeyev, D. et al. (2016) Am. J. Physiol. 310, H426. with permission of The American Physiological Society.
ATX-II (#STA-700) is a highly pure, synthetic, and biologically active peptide toxin.
Applications
Citations
- Cao, Z. et al. (2018) Pharmacology 102, 253.
- Hou, J.W. et al. (2018) Br. J. Pharmacol. 175, 4325.
- Gilchrist, J. and Basmans, F. (2018) J. Physiol. 596, 1863.
- Koleske, M. et al. (2018) J. Gen. Physiol. 150, 991.
- Wei, X.H. et al. (2017) Sci. Rep. 7, 981.
- Hampl, M. et al. (2016) Sci. Rep. 6, 25974.
- Kornyeyev, D. et al. (2016) Am. J. Physiol. 310, H426.
- Baczko, I. et al. (2014) Br. J. Pharmacol. 171, 92.
- Elies, J. et al. (2014) J. Biol. Chem. 289, 16421.
- Viatchenko-Karpinski, S. et al. (2014) J. Mol. Cell. Cardiol. 76, 247.
- Bant, J.S. et al. (2013) J. Neurosci. 33, 4976.
- Blardinelli, L. et al. (2013) J. Pharmacol. Exp. Ther. 344, 23.
Specifications
Scientific Background
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- Anti-SCN4A (NaV1.4) Antibody (#ASC-020)
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