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tBuBHQ

DBHQ
A Potent Inhibitor of Sarcolasmic Reticulum Ca2+ ATPase
Cat #: T-220
Alternative Name DBHQ
Lyophilized Powder yes
Source Synthetic
MW: 222.33
Purity: >97%
Effective concentration 1-10 μM.
Structure
Chemical name 2,5-Ditert-butylbenzene-1,4-diol.
Molecular formula C14H22O2.
CAS No.: 88-58-4.
Activity tBuBHQ is an inhibitor of the endoplasmic reticulum Ca2+-ATPase1.
References-Activity
  1. Kass, G. E.N. et al. (1989) J. Biol. Chem. 264, 15192.
Shipping and storage Up to two years at room temperature.
Solubility Ethanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C.
Protect from light.
References - Scientific background
  1. Ershoff BH. (1969) Proc. Soc. Exp. Biol. Med. 131, 776.
  2. Tsukii. K. et al. (1996) Eur. J. Pharmacol298, 87.
Scientific background tBuBHQ is a chemically synthesized compound1. It is widely used as a potent selective inhibitor of the sarcoplasmic reticulum Ca2+ ATPase pump (SERCA). The pump transfers Ca2+ from the cell cytosol to the endoplasmic reticulum lumen during muscle relaxation. Inhibition of SERCA by tBuBHQ causes a dose-dependent, sustained, and marked increase of cytoplasmatic Ca2+ and store-operated Ca2+ depletion1. tBuBHQ also causes superoxide anion production independently of Ca2+ secretion2.
Target SERCA
Last update: 16/08/2020

tBuBHQ (#T-220) is a highly pure, synthetic, and biologically active compound.

For research purposes only, not for human use
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