Cat #:
T-220
Alternative Name DBHQ
Lyophilized Powder yes
Source Synthetic
MW: 222.33
Purity: >97%
Effective concentration 1-10 μM.
Chemical name 2,5-Ditert-butylbenzene-1,4-diol.
Molecular formula C14H22O2.
CAS No.: 88-58-4
Activity tBuBHQ is an inhibitor of the endoplasmic reticulum Ca2+-ATPase1.
References-Activity
- Kass, G. E.N. et al. (1989) J. Biol. Chem. 264, 15192.
Shipping and storage Up to two years at room temperature.
Solubility Ethanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C.
Protect from light.
Protect from light.
References - Scientific background
- Ershoff BH. (1969) Proc. Soc. Exp. Biol. Med. 131, 776.
- Tsukii. K. et al. (1996) Eur. J. Pharmacol. 298, 87.
Scientific background tBuBHQ is a chemically synthesized compound1. It is widely used as a potent selective inhibitor of the sarcoplasmic reticulum Ca2+ ATPase pump (SERCA). The pump transfers Ca2+ from the cell cytosol to the endoplasmic reticulum lumen during muscle relaxation. Inhibition of SERCA by tBuBHQ causes a dose-dependent, sustained, and marked increase of cytoplasmatic Ca2+ and store-operated Ca2+ depletion1. tBuBHQ also causes superoxide anion production independently of Ca2+ secretion2.
Target SERCA
Lyophilized Powder
Last update: 06/11/2022
tBuBHQ (#T-220) is a highly pure, synthetic, and biologically active compound.
For research purposes only, not for human use
Applications
Citations
Citations
Specifications
Scientific Background
Related Products
Shipping and Ordering information
Need Help With This Product?
Our reagent specialists are here to help you find the best product for your application. Please call or email us and we will be happy to help you find the right product for the job.
Call us at
+972 2587 2202 or Email Us