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Ochratoxin A

A Potent Modulator of Ca2+ ATPase Pump

Cat #: O-400
Lyophilized Powder yes
Origin Aspergillus ochraceus.
Source Natural
MW: 403.8
Purity: >98%
Effective concentration 100 nM - 1 μM.
Structure
Chemical name (-)-N-((5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenylalanine.
Molecular formula C20H18ClNO6.
CAS No.: 303-47-9
Activity Ochratoxin A causes an increase in ATP-driven Ca2+ pump activity in the ER1. Ochratoxin A also induces apoptosis in a JNK-dependent fashion2.
References-Activity
  1. Gekle, M. et al. (2000) J. Pharmacol. Exp. Ther. 293, 837.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or three months at -20°C.
Protect from light.
References - Scientific background
  1. Van der Merwe, K.J. et al. (1965) Nature 205, 1112.
  2. Creppy, E.E. (1999) J. Toxicol. Toxin Rev. 18, 277.
  3. Beardall, J.M. and Miller, J.D.  (1994) In J. D. Miller and H. L. Trenholm (ed.), Eagan Press, St. Paul, Minn. 487.
  4. Chong, X. and Rahimtula, A.D. (1992)  Biochem. Pharmacol. 44, 1401.
Scientific background Ochratoxin A is a natural metabolic alkaloid produce by Aspergillus ochraceus1. Ochratoxin A is a potent a toxin which causes nephrosis in mammals. In the circulation, Ochratoxin A has a very long half-life in all species examined2. Although the kidney is the primary target organ for Ochratoxin A activity, studies indicate that Ochratoxin A is also a liver toxin, immunosuppressant, potent teratogen, and carcinogen3. Ochratoxin A increases activity of the endoplasmic reticulum ATP-dependent Ca2+ pump4.
Target SERCA pump
Lyophilized Powder
Last update: 02/01/2022

Ochratoxin A (#O-400) is a highly pure, natural, and biologically active compound.

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