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Thapsigargin, derived from the plant genus Thapsia1,2, is an extremely tight-binding inhibitor of intracellular Ca2+ pumps. It was initially described as a tumor promoting agent that induces rapid Ca2+ release from intracellular stores3 by the inhibition of the sarcoplasmic endoplasmic reticulm Ca2+-dependent ATPase pump without inositol phosphate formation4. Thapsigargin-induced depletion of Ca2+ stores causes apoptosis in most cell lines5. It has also been shown to cause histamine secretion from rat mast cells6 and to stimulate arachidonic acid metabolism in macrophages7. Its tumour-promoting function probably results, at least partly, from cytotoxicity, causing a wound response in the skin8.
Thapsigargin Epoxide is a non-active analogue of Thapsigargin and can be used as a negative control for Thapsigargin activity9,10.
Thapsigargin Epoxide (#T-670) is a highly pure, natural, and biologically active compound.