Extracellular antibodies are ideal research tools for cell-surface proteins.
No permeabilization/fixation because using extracellular antibodies allows you to work with live cells!
Benefits of live cell imaging:
✓ Monitor cell movement
✓ Study protein transport across the cell
✓ Investigate protein internalization
Inwardly rectifying K+ (Kir) channels have diverse physiological functions depending on their type and their location. To date, 15 Kir subunit genes have been identified and classified into seven subfamilies (Kir1 to Kir7). These subfamilies can be categorized into four functional groups: 1) classical Kir channels (Kir2.x), 2) G-protein gated Kir channels (Kir3.x), 3) ATP-sensitive K+ channels (Kir6.x), and 4) K+-transport channels (Kir1.x, Kir4.x, Kir5.x, and Kir7.x).