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Neuropilins

The neuropilins (Nrps) are single-pass multifunctional transmembrane glycoproteins that play an important role in cell development, immunity and cancer, physiological and pathological angiogenesis. They were first discovered as regulators of nervous system development, acting as semaphorin coreceptors with plexins and also enhance cellular responses to members of the vascular endothelial growth factor (VEGF) family.