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P2X7 Receptor Antagonist Explorer Kit

A Screening Package of P2X7 Receptor Antagonists Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
Cat #: EK-410
Sizes: 13 Vials
Last update: 01/04/2019

P2X7 Receptor Antagonist Explorer Kit (#EK-410) contains P2X7 receptor antagonists, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product Name Cat # Size
A-740003
 		A-420 1 x 10 mg
A-804598
 		A-415 1 x 5 mg
A-839977
 		A-470 1 x 5 mg
AACBA hydrochloride
 		A-410 1 x 5 mg
AZ 10606120 dihydrochloride
 		A-405 1 x 5 mg
AZ11645373
 		A-395 1 x 5 mg
AZD-9056 hydrochloride
 		A-425 1 x 1 mg
CAY10593 (VU0155069)
 		C-385 1 x 5 mg
GW 791343 hydrochloride
 		G-115 1 x 5 mg
JNJ-47965567
 		J-115 1 x 5 mg
JNJ-54166060
 		J-125 1 x 5 mg
KN-62
 		K-120 1 x 1 mg
ZINC58368839
 		Z-135 1 x 5 mg
References
Scientific Background P2X7 receptor is a member of the ionotropic P2X receptor family, activated by ATP. P2X7 receptor is found in cells of the immune system, particularly antigen presenting cells, and microglia. P2X7 receptor mediates the release of proinflamatory cytokines, stimulation of transcription factors and may also have an important role in apoptosis1-3.
References
  1. Ding, Y. et al. (2000) J. Auton. Nerv. Syst. 81, 289.
  2. Kim, M. et al. (2001) EMBO J. 20, 6347.
  3. Chizh, B.A. and Illes, P. (2001) Pharmacol. Rev. 53, 553.
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