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Voltage-Gated Cl- Channels

CLC channels are often subdivided based on their subcellular location: channels that are expressed at the plasma membrane (CLC-1, CLC-2, CLC-Ka and CLC-Kb) and channels that are located in intracellular organelles (CLC-3 to CLC-7). Strong evidence suggest that at least CLC-4, CLC-5 and CLC-7 function as Cl/H+ antiporters, that couple Cl influx to H+ efflux.

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