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5-Chloroindole

A Positive Allosteric Modulator of 5-HT3 Receptors

Cat #: C-260
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 151.6
    Purity: >98%
    Effective concentration 1-100 µM.
    Structure
    Chemical name 5-chloro-1H-indole.
    Molecular formula C8H6ClN.
    CAS No.: 17422-32-1
    PubChem CID 87110
    Activity 5-Chloroindole is a potent and selective allosteric modulator of the 5-HT3 receptor that displays micromolar potency1.
    References-Activity
    1. Newman, A.S. et al. (2013) Br. J. Pharmacol. 169, 1228.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs 5-Chloroindole potentiates the response to 5-HT of 5-HT3A receptors expressed in HEK 293T cells. 
      Alomone Labs 5-Chloroindole potentiates the response to 5-HT of 5-HT3A receptors expressed in HEK 293T cells. 
      5-HT3A receptor currents were elicited by 1 µM 5-HT, delivered every 3 minutes. 5-Chloroindole (#C-260) was applied 30 seconds before stimulation at 1, 10 and 100 µM, as indicated, and enhanced the 5-HT induced current in a dose-dependent and reversible manner.
    References - Scientific background
    1. Newman, A.S. et al. (2013) Br. J. Pharmacol. 169, 1228.
    2. Scendo, M. et al. (2003) J. Appl. Electrochem. 33, 287.
    3. Sherman, A.D. and Gál, E.M. (1976) Psychopharmacol. Commun. 2, 285.
    Scientific background

    5-Chloroindole is a potent and selective allosteric modulator of the 5-HT3 receptor that displays micromolar potency.

    The 5-HT3 receptor belongs to the Cys-loop ligand-gated ion channel superfamily. It mediates fast synaptic neurotransmission in neurons of both the central and peripheral nervous systems.

    5-Chloroindole can assist in the investigation of the molecular basis for allosteric modulation of the 5-HT3 receptor and may contribute to the discovery of novel therapeutic drugs targeting the 5-HT3 receptor1. 5-Chloroindole is also used as a strong inhibitor of the copper dissolution in acidic sodium chloride solution2. Several different studies have shown that 5-chloroindole has the ability to decrease serotonin levels in the brainstem and in the telencephalon3.

    Target 5-HT3 receptors
    Lyophilized Powder
    Last update: 06/11/2022

    5–Chloroindole (#C-260) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use
    Shipping and Ordering information

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