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3-4. Anti-GFR alpha 4 (extracellular) Antibody, preincubated with the control peptide antigen.
The GDNF family ligands (GFLs) belong to the super family of the TGF-β. They belong to the group of cystine-knot protein and function as homodimers1. This family includes glial cell line-derived neurotrophic factor (GDNF), artemin (ARTN), Neurturin (NRTN) and persephin (PSPN)2.
These factors are heavily involved in the development and function of the nervous system (both central and peripheral). In particular GDNF has an important role outside the nervous system where it plays a role in kidney morphogenesis1.
In general GFLs all signal through a signal through the receptor tyrosine kinase Ret. Their specificity is implemented by different GDNF family receptor a (GFRα), which act as co-receptors. These extracellular proteins are bound to the plasma membrane via a glycosyl phosphatidyl inositol (GPI) anchor. GFRα1-4 are responsible for the binding of GDNF, NRTN, ARTN, and PSPN respectively and the subsequent activation of Ret. Soluble forms of the receptor by the cleavage of a yet unknown phospholipase or protease can be detected1,3. Also alternative spliced forms of the protein can lead to soluble forms of GFRα receptors3.
Species reactivity key:
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of rat GFRα4 receptor. Anti-GFR alpha 4 (extracellular) Antibody (#ANT-024) can be used in western blot analysis, immunohistochemical and immunocytochemical applications. Anti-GDNF Family Receptor α4 (extracellular) is highly suitable to be used in live cell imaging. It has been designed to recognize GFRα4 from mouse and rat samples. The antibody is not suitable for detecting GFRα4 from human samples.