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4-6. Anti-Ghrelin Receptor (extracellular) Antibody, preincubated with the control peptide antigen.
Ghrelin is a 28 amino acid peptide, acylated on a serine residue which is essential for its biological activity1,2. In rodents, an additional form of the peptide could be purified. The peptide is released from the stomach and exerts its effect on the ghrelin receptor (GHS-R). GHS-R is a member of the G-protein coupled receptor (GPCR) superfamily. Like all members, the receptor has seven transmembrane spanning domains and upon activation it stimulates phospholipase C, thereby increasing IP3 and intracellular Ca2+ levels1,3.
GHS-R is expressed in the hypothalamus, pituitary and hippocampus1,3.
Some of the actions of ghrelin include the stimulation of growth hormone release, food intake, fat accumulation, regulation of memory and learning, activation of reward-related pathways and neuroprotection to name a few1,3.
GHS-R 1b is a truncated form of the full length receptor which is also expressed. Although its exact functions are unknown, it is believed that it may be involved in downregulating signaling from the full length receptor4. In addition, it is overexpressed in lung cancer where it dimerizes with neurotensin receptor4,5.
Species reactivity key:
Anti-Ghrelin Receptor (extracellular) Antibody (#AGR-031) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, live cell imaging, and immunocytochemistry applications. It has been designed to recognize ghrelin receptor from human, mouse, and rat samples.
Antibodies for live cell flow cytometry experiments
- Anti-Ghrelin Receptor (extracellular)-FITC Antibody (#AGR-031-F). This FITC-conjugated antibody can be used to detect Ghrelin receptor in live cell flow cytometry.