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- Peptide CKASGDLEQGKKDS, corresponding to amino acid residues 319-332 of mouse OXGR1 (Accession Q6IYF8). Intracellular, C-terminus.
- Western blot analysis of mouse kidney (lanes 1 and 4), rat kidney (lanes 2 and 5) (1:600) and rat testis (lanes 3 and 6) (1:200) lysates:1-3. Anti-OXGR1/GPR99 Antibody (#AOR-016).
4-6. Anti-OXGR1/GPR99 Antibody, preincubated with the negative control antigen.
Oxoglutarate receptor 1 (OXGR1) is a receptor for α-ketoglutarate (αKG), a metabolite that is a citric acid cycle intermediate and a glutamine catabolism by-product1. αKG also serves as a metabolic marker and its interaction with OXGR1 has been shown to mediate the adaptive regulation of HCO3– secretion and NaCl reabsorption under acid-base stress3.
OXGR1 belongs to the G-protein coupled receptor (GPCRs) protein family. Members of this group contain seven trans-membrane domains and respond to a large variety of ligands and thereby affect key cellular functions that are crucial for cell survival or proliferation2. OXGR1 belongs to a subset of metabolic GPCRs, along with receptors for succinate (GPR91), lactate (GPR81), fatty acids (FFAR) and many more3.
OXGR1 is expressed in the kidney3,4 and in the heart, where it affects the contractile function, consistent with the finding that α-ketoglutarate levels are high in heart failure patients5.
Because of its major role in maintaining cellular balance and its role in heart contractile activity, identification of molecules that can specifically activate or inhibit this receptor may be very useful in the development of novel therapeutic approach for pathological cardiac hypertrophy5.
Species reactivity key:
Anti-OXGR1/GPR99 Antibody (#AOR-016) is a highly specific antibody directed against an epitope of the mouse Oxoglutarate receptor 1. The antibody can be used in western blot analysis. It has been designed to recognize OXGR1 from rat, mouse, and human samples.