This product is freeze dried. All water molecules have been removed.
The activity of this product has been verified and approved by our professional team.
Calcicludine is a natural peptide isolated from the Dendroaspis angusticepsgreen mamba venom by a modification to the procedure of Schweitz et al.1 and purified to homogenity.
Calcicludine was shown to be a specific neuronal L-type CaV channel blocker and was shown to inhibit other neuronal HVA CaV channels (N- and P-type) as well.1 1 µM Calcicludine had no effect on skeletal muscle CaV channels (CaV1.1) as well as on T-type (CaV3) channels in heart and neurons.1 Calcicludine was tested to confirm its ability to block spontaneous or K+-induced contraction of cardiac cells.1 It blocked CaV1.2 cloned channels with an IC50 of 88 nM and had very little effect on CaV2 family channels.2 In addition, the block was irreversible upon wash and never complete but reached a maximum of 58%.
Calcicludine (#SPC-650) is a highly pure, synthetic, and biologically active peptide toxin.