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Diferuloylmethane, Natural yellow 3, Turmeric yellow, Turmeric

An Activator of TRPA1 Channels

Cat #: C-230
Alternative Name Diferuloylmethane, Natural yellow 3, Turmeric yellow, Turmeric
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Curcuma longa L. root.
    Source Natural
    MW: 368.4
    Purity: >96%
    Form Lyophilized powder.
    Effective concentration 10-200 µM.
    Chemical name (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione.
    Molecular formula C21H20O6.
    CAS No.: 458-37-7
    PubChem CID 969516
    Activity Curcumin activates TRPA1 channels with an EC50 of 10 µM1.
    1. Leamy, A.W. et al. (2011) Neurosci. Lett. 503, 157.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Curcumin activates TRPA1 channels expressed in HEK-293 cells. 
      Alomone Labs Curcumin activates TRPA1 channels expressed in HEK-293 cells. 
      Dose-response curve for the activation of human TRPA1 expressing HEK-293 cells loaded with Calcium 5 dye for changes in intracellular Ca2+ measurements. Calcium signal was apparent with 100 µM Curcumin (#C-230).
    Note Total Curcuminoids 96.2% HPLC
    Curcumin 75.4% HPLC
    Demethoxy curcumin 18.8% HPLC
    Bisdemethoxy curcumin 2.96% HPLC
    References - Scientific background
    1. Cvetkov, T.L. et al. (2011) J. Biol. Chem. 286, 38168.
    2. Lim, G.P. et al. (2001) J. Neurosci. 21, 8670.
    3. Samuhasaneeto, S. et al. (2009) J. Biomed Biotech. 2009, 8.
    4. Pan, Y. et al. (2007) Mol. Cells 25, 531.
    Scientific background

    Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channel expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and neuropathic pain signals. Numerous non-reactive compounds and electrophilic compounds, such as endogenous inflammatory mediators and exogenous pungent chemicals, can activate TRPA11.

    Curcumin is a natural agonist of TRPA1 channels produced from the root Curcuma longa L. with an effective concentration of 10-200 μM and an EC50 of 10 μM. Curcumin is hypothesized to be effective in the prevention and alleviation of various pathologies. Curcumin significantly lowers oxidized proteins, GFAP marker levels and β-amyloid plaques in a mouse model of Alzheimer’s disease2. In rats, curcumin reduces liver damage caused by gastric ethanol infusion. This is mainly done by decreasing hepatic MDA, inhibiting NF-κB activation and reducing apoptosis of hepatic cells thus improving hepatic histopathology and reducing the morbidity associated with alcoholic liver disease3. Also, MDX mice treated with curcumin show improvement of grip strength in a dose-dependent manner and a reduction of the CK marker which indicates skeletal muscle injury4.

    Target TRPA1 channels
    Last update: 02/01/2022

    Curcumin (#C-230) is a highly pure, natural, and biologically active compound.

    For research purposes only, not for human use
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