Overview
- Leamy, A.W. et al. (2011) Neurosci. Lett. 503, 157.
Alomone Labs Curcumin activates TRPA1 channels expressed in HEK-293 cells.Dose-response curve for the activation of human TRPA1 expressing HEK-293 cells loaded with Calcium 5 dye for changes in intracellular Ca2+ measurements. Calcium signal was apparent with 100 µM Curcumin (#C-230).
Curcumin 75.4% HPLC
Demethoxy curcumin 18.8% HPLC
Bisdemethoxy curcumin 2.96% HPLC
- Cvetkov, T.L. et al. (2011) J. Biol. Chem. 286, 38168.
- Lim, G.P. et al. (2001) J. Neurosci. 21, 8670.
- Samuhasaneeto, S. et al. (2009) J. Biomed Biotech. 2009, 8.
- Pan, Y. et al. (2007) Mol. Cells 25, 531.
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channel expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and neuropathic pain signals. Numerous non-reactive compounds and electrophilic compounds, such as endogenous inflammatory mediators and exogenous pungent chemicals, can activate TRPA11.
Curcumin is a natural agonist of TRPA1 channels produced from the root Curcuma longa L. with an effective concentration of 10-200 μM and an EC50 of 10 μM. Curcumin is hypothesized to be effective in the prevention and alleviation of various pathologies. Curcumin significantly lowers oxidized proteins, GFAP marker levels and β-amyloid plaques in a mouse model of Alzheimer’s disease2. In rats, curcumin reduces liver damage caused by gastric ethanol infusion. This is mainly done by decreasing hepatic MDA, inhibiting NF-κB activation and reducing apoptosis of hepatic cells thus improving hepatic histopathology and reducing the morbidity associated with alcoholic liver disease3. Also, MDX mice treated with curcumin show improvement of grip strength in a dose-dependent manner and a reduction of the CK marker which indicates skeletal muscle injury4.
Curcumin (#C-230) is a highly pure, natural, and biologically active compound.
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