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A Novel Photosensitive Activator of TRPA1 Channel

Cat #: O-140
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 315.41
    Purity: >98%
    Effective concentration 10-100 µM.
    Chemical name (5E)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one.
    Molecular formula C15H13N3OS2.
    CAS No.: 348575-88-2
    PubChem CID 1365101
    Activity Optovin is a photosensitive TRPA1 ligand that activates TRPA1 channels in vitro and facilitates repeated photoactivation of motor behaviors in vivo (EC50 = 2 µM) when reversibly activated by violet light (405 nm)1.
    1. Kokel, D. et al. (2013) Nat. Chem. Biol. 9, 257.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Protect from light.
    Solubility Soluble in DMSO.
    Centrifuge all products before use (10000 x g 5 min).
    Storage of solutions Up to three months at -20°C.
    Our bioassay
    • Alomone Labs Optovin activates TRPA1 channels expressed in HEK-293 cells.
      Alomone Labs Optovin activates TRPA1 channels expressed in HEK-293 cells.
      Dose-response curve of the activation of human TRPA1 channels by increasing concentrations of Optovin (#O-140). Cells were loaded with Calcium 5 dye. Changes in intracellular Ca2+ following Optovin application were detected as changes in relative fluorescence (RFU). EC50 was determined at 18.3 µM.
    References - Scientific background
    1. Kokel, D. et al. (2013) Nat. Chem. Biol. 9, 257.
    2. Klionsky, L. et al. (2007) Mol. Pain 3, 39.
    Scientific background

    Optovin, a novel neuroactive small molecule, acts as a photosensitive TRPA1 (transient receptor potential ankyrin 1) channel activator win EC50 values of 2 µM1. Optovin is a rhodanine derivative and activates TRPA1 channels in vitro and facilitates repeated photoactivation of motor behaviors in vivo1.

    In humans, Optovin activates TRPA1 channels through structure-dependent photochemical reactions with redox-sensitive cysteine residues. In animals with severed spinal cords Optovin enables control of motor activity in the paralyzed extremities by localized illumination1.

    TRPA1 channels are non-selective cation channels expressed in the small neurons of the dorsal root and trigeminal ganglia. They play an important role in models of inflammatory and neuropathic pain and have the ability to detect pungent or irritant compounds2.

    Target TRPA1 channels
    Last update: 06/11/2022

    Optovin (#O-140) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use



    Scientific Background

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