TRPA1 Channel Modulator Explorer Kit

A Screening Package of TRPA1 Channel Modulators Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
  • Shipped at Room Temp.
  • 100% Net Peptide
Cat #: EK-120
Sizes: 14 Vials
Last update: 25/12/2017

The TRPA family is comprised of only one mammalian member, the TRPA1 (formerly named ANKTM1). TRPA1 is expressed in peripheral sensory neurons, where it is suggested to contribute to the detection of painful stimuli.1

Originally it was thought that TRPA channels sensed painfully cold temperatures2, but a more conservative description is that TRPA1 is sensitive to membrane/cytoskeletal perturbations by cold3-5 and perhaps stretch.6 In addition, it is sensitive to pungent natural compounds present in cinnamon oil, mustard oil, and wintergreen oil.

Alomone Labs is pleased to offer the TRPA1 Channel Modulator Explorer Kit (#EK-120). The Explorer Kit contains TRPA1 blockers and activators, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
A 967079
A-225 1 x 5 mg
AP-18
A-250 1 x 5 mg
Capsiate
C-255 1 x 5 mg
Chembridge-5861528
C-235 1 x 5 mg
Curcumin
C-230 1 x 5 g
DMA
D-165 1 x 5 mg
Etodolac
E-140 1 x 10 mg
Glibenclamide
G-150 1 x 1 g
HC-030031
H-105 1 x 10 mg
Ligustilide
L-170 1 x 10 mg
4-ONE
O-145 1 x 5 mg
Ononetin
O-135 1 x 50 mg
Optovin
O-140 1 x 5 mg
ProTx-I
STP-400 1 x 0.1 mg
References
References
  1. Hill, K. and Schaefer, M. (2007) J. Biol. Chem. 282, 7145
  2. Zurborg, S. et al. (2007) Nat. Neurosci. 10, 277.
  3. Bandell, M. et al. (2004) Neuron 41, 849.
  4. Corey, D.P. et al. (2004) Nature 432, 723.
  5. Jordt, S.E. et al. (2004) Nature 427, 260.
  6. Story, G.M. et al. (2003) Cell 112, 819.
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