ENaC Antibody Explorer Kit

A Screening Package of ENaC Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
  • Shipped at Room Temp.
Cat #: AK-570
Sizes: 6 Vials
Last update: 03/09/2018

Alomone Labs is pleased to offer the ENaC Antibody Explorer Kit (#AK-570). The Explorer Kit contains ENaC antibodies, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-ENaCα (extracellular) Antibody
ASC-030 1 x 50 µl
Anti-ENaCβ (extracellular) Antibody
ASC-019 1 x 50 µl
Anti-ENaCγ (extracellular) Antibody
ASC-011 1 x 50 µl
Scientific Background
Scientific Background

The DEG/ENaC family consists of Na+ selective channels. They are characterized by 2 transmembrane domains with a large extracellular loop, important for channel activity and intracellular N-and C-termini which are important for channel gating and for interacting with regulatory proteins respectively1,2.

ENaC is localized to the apical side of polarized epithelial cells like those in the kidney, lung, and distal colon and is responsible for maintaining proper Na+ balance. This channel is formed by oligomerization of three subunits, α, β, and γ usually with the α2β1γ1 combination2,3. In addition, the α subunit which is essential for channel activity undergoes phosphorylation in its C-terminal by SGK1 (serum and glucocorticoid-induced kinase 1) which is known to activate the channel at the plasma membrane4.

References
  1. Árnadóttir, J. and Chalfie, M. (2010) Annu. Rev. Biophys39, 111.
  2. Schild, L. (2010) Biochim. Biophys. Acta 1802, 1159.
  3. Soundararajan, R. et al. (2010) J. Biol. Chem. 285, 30363.
  4. Diakov, A. and Korbmacher, C. (2004) J. Biol. Chem. 279, 38134.
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