- Chow, C.Y. et al. (2020) ACS Pharmacol. Transl. Sci. 3, 119.
- Alomone Labs Hj1a Toxin enhances NaV1.1 channel currents expressed in HEK293 cells.Representative superimposed traces of NaV1.1 currents in the absence (black) or presence (red) of 1 µM Hj1a Toxin (#STH-450). Currents were elicited by a 20 ms voltage step to potentials ranging from -80 to +40 mV in 10 mV increments from a holding potential of -120 mV.
This figure was kindly provided by the lab of Dr. Moran Rubinstein, Goldschleger Eye Research Institute, The Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University.
Hj1a is a peptide toxin originally isolated from the Hottentotta jayakari scorpion venom. Hj1a acts as a potent NaV1.1 channel activator. Hj1a is unique in that it presents a dual α/β activity by modifying both the activation and inactivation properties of the channel1.
NaV1.1 is predominantly expressed in inhibitory interneurons of the brain and it plays a major role in regulating brain rhythms and cognitive functions. Mutations in NaV1.1 channel were shown to be related to Dravet syndrome (DS), a severe form of pediatric epilepsy. NaV1.1 selective modulators can be useful therapeutics for treatment of DS as they target the underlying molecular deficit2.
Hj1a Toxin (#STH-450) is a highly pure, synthetic, and biologically active peptide toxin.