NaV Channel Activator Explorer Kit

A Screening Package of NaV Channel Activators Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
  • Shipped at Room Temp.
  • 100% Net Peptide
Cat #: EK-203
Sizes: 12 Vials
Last update: 25/12/2017

Voltage-gated sodium channels (Nav) are essential for the generation of action potentials and for cell excitability.1 Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions.

To date, nine Nav α subunits have been cloned and named Nav1.1-Nav1.9.4-5  The Nav channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7)  and TTX-resistant (Nav1.5, Nav1.8 and Nav1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific.

Alomone Labs is pleased to offer the NaV Channel Activator Explorer Kit (#EK-203). This Explorer Kit is ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Aconitine
A-150 1 x 5 mg
Anthopleurin-C
A-400 1 x 5 µg
ATX-II
STA-700 1 x 50 µg
BDS-I
STB-400 1 x 0.1 mg
Jingzhaotoxin-II
STJ-150 1 x 50 µg
α-Pompilidotoxin
P-170 1 x 1 mg
1Kα-Pompilidotoxin
P-172 1 x 1 mg
3Rα-Pompilidotoxin
P-174 1 x 1 mg
3R12Rα-Pompilidotoxin
P-176 1 x 1 mg
β-Pompilidotoxin
P-180 1 x 1 mg
1Kβ-Pompilidotoxin
P-182 1 x 1 mg
Veratridine
V-110 1 x 5 mg
References
References
  1. Lai, J. et al. (2003) Curr. Opin. Neurobiol 13, 291.
  2. Fang, X. et al. (2002) J. Neurosci22, 7425.
  3. Wu, L. et al. (2002) Neuroreport 13, 2547.
  4. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27.
  5. Fjell, J. et al. (2000) NeuroReport 11, 199.
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