IRL-1620

Suc-[Glu9, Ala11,15] Endothelin-1, (8-21)
A Selective and Potent Endothelin B Receptor Agonist
    Cat #: SPE-220
    Alternative Name Suc-[Glu9, Ala11,15] Endothelin-1, (8-21)
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1820 Da.
    Purity: ≥98% (HPLC)
    Effective concentration 1 pM -100 nM.
    Sequence DEEAVYFAHLDIIW.
    Modifications Asp1 = Suc-Asp.
      • IRL-1620
    Molecular formula C86H117N17O27.
    CAS No.: 142569-99-1.
    Activity IRL-1620 is a selective and potent ET-B receptor agonist1,2.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
      • IRL-1620
        Alomone Labs IRL-1620 activates Endothelin B receptor-mediated Ca2+ mobilization in CHO-K1-mt Aequorin cells.
        Dose-response curve of normalized activation of Endothelin B receptor-mediated Ca2+ mobilization, evoked by IRL-1620 (#SPE-220). Ca2+ response was detected by measuring aequorin-derived fluorescence following application of IRL-1620 and Endothelin-1 at different concentrations. The EC50 measured for IRL-1620 is 1.53 nM.
    References - Scientific background
      • IRL-1620 is a synthetic peptide that acts as a selective and potent ET-B (endothelin B) receptor agonist, a receptor belonging to the G-protein coupled receptors (GPCR) superfamily. IRL-1620 is a C-terminal linear peptide analog of endothelin (ET-1) with a structure that is based on the carboxy-terminal end of ET-1. IRL-1620 has the ability to produce vasodilation or vasoconstriction1.

        Endothelin 1 (ET-1) and its receptor ET-B play an important role in regulating renal function and blood pressure. ET-B receptor and ET-1 are both expressed in sensory nerves. They are mainly present in medium- and large-sized cell bodies of human trigeminal ganglia2.

        Studies have shown that acute administration of an ET-B receptor agonist into the rat renal medulla leads to natriuresis and diuresis via a mechanism that is NOS1-dependent3.

    Target ET-B receptor
    Net Peptide Content: 100%
    Last update: 27/01/2020

    IRL-1620 (#SPE-220) is a highly pure, synthetic, and biologically active peptide.

    For research purposes only, not for human use