Muscle Specific nAChR Antagonist Explorer Kit

A Screening Package of Muscle Specific nAChR Antagonists Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
Cat #: EK-207
Last update: 24/01/2020

Alomone Labs is pleased to offer the Muscle Specific nAChR Antagonist Explorer Kit (#EK-207). This Explorer Kit includes muscle-type specific nAChR antagonists. An ideal tool for screening purposes.

For research purposes only, not for human use


Product NameCat #Size
α-Conotoxin EI
STC-900 1 x 0.1 mg
α-Conotoxin GI
STC-500 1 x 50 µg
α-Conotoxin MI
STC-370 1 x 0.1 mg
α-Conotoxin SI
STC-825 1 x 50 µg
αA-Conotoxin OIVA
STC-520 1 x 10 µg
αA-Conotoxin PIVA
STC-600 1 x 50 µg
αC-Conotoxin PrXA
STC-620 1 x 50 µg
STA-100 1 x 0.1 mg
(-)-Lobeline hydrochloride
L-120 1 x 100 mg
STW-001 1 x 1 mg

Scientific Background

    • All α subunits are expressed in neuronal cells except for the α1 subunit which is specifically expressed in skeletal muscle. Indeed, two different nAChR structural entities with the following stoichiometry are observed in this tissue: (α1)2β1δγ in fetal muscle cells and (α1)2β1δε at mature neuromuscular synapses.

      The α1 extracellular domain contains the main immunogenic region, a region against which a large fraction of autoantibodies against nAChR is directed in the autoimmune disease myasthenia gravis (MG). This autoimmune disease is characterized by the malfunction of neuromuscular transmission as a result of nonfunctional nAChRs, leading to defective signaling at the neuromuscular junction.

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