Na+/H+ Exchanger (NHE) Antibody Explorer Kit

A Screening Package of Na+/H+ Exchanger (NHE) Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
  • Shipped at Room Temp.
Cat #: AK-610
Sizes: 10 Vials
Last update: 13/09/2018

Na+/H+ Exchanger (NHE) Antibody Explorer Kit (#AK-610) is a budget friendly screening package.

For research purposes only, not for human use
Scientific Background
Scientific Background

In order to function in optimal conditions, cells must maintain a close to neutral intracellular pH. They have adopted various mechanisms in order to do so, one of which is via Na+/H+ exchangers (NHEs). Genes belonging to this group are expressed along a very broad range of organisms and are essential for protecting cells against intracellular acidification1.

To date, nine genes have been identified in mammals; NHE1-9. These membrane proteins have 10-12 transmembrane domains depending on whether a splice variant is expressed and an intracellular N-terminal. The C-terminal domain can be either intracellular or extracellular, also depending whether a splice variant of the protein is involved. The C-terminal part of the protein also undergoes posttranslational modification such as phosphorylation2.

Under physiological conditions, the Na+/H+ exchanger mediates the exchange of one extracellular Na+ ion for one intracellular proton, thereby keeping the overall charge neutral1.

  1. Counillon, L. and Pouyssegur, J. (2000) J. Biol. Chem. 275, 1.
  2. Kemp, G. et al. (2008) Channels 2, 329.
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