Overview
Na+/H+ Exchanger (NHE) Antibody Explorer Kit (#AK-610) is a budget friendly screening package.
Compounds
Product Name | Cat # | Size |
---|---|---|
Anti-Na+/H+ Exchanger 1 (NHE-1) (extracellular) Antibody |
ANX-010 | 1 x 50 µl |
Na+/H+ Exchanger 1/NHE-1 (extracellular) Blocking Peptide |
BLP-NX010 | 1 x 40 µg |
Anti-Na+/H+ Exchanger 2 (NHE-2) Antibody |
ANX-002 | 1 x 50 µl |
Na+/H+ Exchanger 2/NHE-2 Blocking Peptide |
BLP-NX002 | 1 x 40 µg |
Anti-Na+/H+ Exchanger 3 (NHE-3) Antibody |
ANX-033 | 1 x 50 µl |
Na+/H+ Exchanger 3/NHE-3 Blocking Peptide |
BLP-NX033 | 1 x 40 µg |
Anti-Na+/H+ Exchanger 5 (NHE-5) Antibody |
ANX-005 | 1 x 50 µl |
Na+/H+ Exchanger 5/NHE-5 Blocking Peptide |
BLP-NX005 | 1 x 40 µg |
Anti-Na+/H+ Exchanger 6 (NHE-6) Antibody |
ANX-006 | 1 x 50 µl |
Na+/H+ Exchanger 6/NHE-6 Blocking Peptide |
BLP-NX006 | 1 x 40 µg |
Scientific Background
In order to function in optimal conditions, cells must maintain a close to neutral intracellular pH. They have adopted various mechanisms in order to do so, one of which is via Na+/H+ exchangers (NHEs). Genes belonging to this group are expressed along a very broad range of organisms and are essential for protecting cells against intracellular acidification1.
To date, nine genes have been identified in mammals; NHE1-9. These membrane proteins have 10-12 transmembrane domains depending on whether a splice variant is expressed and an intracellular N-terminal. The C-terminal domain can be either intracellular or extracellular, also depending whether a splice variant of the protein is involved. The C-terminal part of the protein also undergoes posttranslational modification such as phosphorylation2.
Under physiological conditions, the Na+/H+ exchanger mediates the exchange of one extracellular Na+ ion for one intracellular proton, thereby keeping the overall charge neutral1.
- Counillon, L. and Pouyssegur, J. (2000) J. Biol. Chem. 275, 1.
- Kemp, G. et al. (2008) Channels 2, 329.
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