Na+/H+ Exchanger (NHE) Antibody Explorer Kit

A Screening Package of Na+/H+ Exchanger (NHE) Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-610
Last update: 24/01/2020

Na+/H+ Exchanger (NHE) Antibody Explorer Kit (#AK-610) is a budget friendly screening package.

For research purposes only, not for human use

Scientific Background

Scientific Background
    • In order to function in optimal conditions, cells must maintain a close to neutral intracellular pH. They have adopted various mechanisms in order to do so, one of which is via Na+/H+ exchangers (NHEs). Genes belonging to this group are expressed along a very broad range of organisms and are essential for protecting cells against intracellular acidification1.

      To date, nine genes have been identified in mammals; NHE1-9. These membrane proteins have 10-12 transmembrane domains depending on whether a splice variant is expressed and an intracellular N-terminal. The C-terminal domain can be either intracellular or extracellular, also depending whether a splice variant of the protein is involved. The C-terminal part of the protein also undergoes posttranslational modification such as phosphorylation2.

      Under physiological conditions, the Na+/H+ exchanger mediates the exchange of one extracellular Na+ ion for one intracellular proton, thereby keeping the overall charge neutral1.

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