|Product Name||Cat #||Size|
|D-125||1 x 1 g|
|C-130||1 x 10 mg|
|D-110||1 x 5 mg|
|I-110||1 x 250 mg|
|N-175||1 x 1 g|
|P-110||1 x 5 mg|
RJR 2403 oxalate
|R-115||1 x 5 mg|
|V-105||1 x 5 mg|
- Lyophilized Powder Lyophilized Powder
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- Bioassay Tested Bioassay Tested
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- Shipped at Room Temp. Shipped at Room Temp.
This lyophilized product is shipped at room temperature. Please see its certificate of analysis for further storage instructions.
Acetylcholine, released by cholinergic neurons, activates two groups of acetylcholine receptors (AChRs); muscarinic AChRs (mAChRs) which belong to the superfamily of G-protein coupled receptors (GPCRs) and nicotinic AChRs (nAChRs) which belong to the ligand-gated ion channel superfamily. nAChRs also respond to nicotine, hence their name1.
To date, 17 different but related subunits of nAChRs have been identified and cloned. They consist of α subunits (α1-10), which is responsible for the binding of ligands. In fact, this subunit includes a Cys-loop in the first extracellular domain that is required for agonist binding2. The other subunits responsible for making up the active receptor are the β (β1-4), γ, δ and ε subunits3. Structurally, all subunits have the following: a conserved large extracellular N-terminal domain, 3 conserved transmembrane domains, a variable cytoplasmic loop and a fourth transmembrane domain with a short extracellular C-terminal domain. An active nAChR is generally a heteropentamer of these various subunits organized around a central pore1.
nAChRs are validated therapeutic targets for various CNS pathologies4.
Alomone Labs is pleased to offer the nAChR Agonist Explorer Kit (#EK-204). This Explorer Kit includes nAChR agonists, ideal for screening purposes.