nAChR Agonist Explorer Kit

A Screening Package of nAChR Activators Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
  • Shipped at Room Temp.
Cat #: EK-204
Sizes: 8 Vials
Last update: 25/12/2017

Acetylcholine, released by cholinergic neurons, activates two groups of acetylcholine receptors (AChRs); muscarinic AChRs (mAChRs) which belong to the superfamily of G-protein coupled receptors (GPCRs) and nicotinic AChRs (nAChRs) which belong to the ligand-gated ion channel superfamily. nAChRs also respond to nicotine, hence their name1.

To date, 17 different but related subunits of nAChRs have been identified and cloned. They consist of α subunits (α1-10), which is responsible for the binding of ligands. In fact, this subunit includes a Cys-loop in the first extracellular domain that is required for agonist binding2. The other subunits responsible for making up the active receptor are the β (β1-4), γ, δ and ε subunits3. Structurally, all subunits have the following: a conserved large extracellular N-terminal domain, 3 conserved transmembrane domains, a variable cytoplasmic loop and a fourth transmembrane domain with a short extracellular C-terminal domain.  An active nAChR is generally a heteropentamer of these various subunits organized around a central pore1.

nAChRs are validated therapeutic targets for various CNS pathologies4.

Alomone Labs is pleased to offer the nAChR Agonist Explorer Kit (#EK-204). This Explorer Kit includes nAChR agonists, ideal for screening purposes.

For research purposes only, not for human use
Product NameCat #Size
1,1-Dimethyl-4-phenylpiperazinium iodide
D-125 1 x 1 g
C-130 1 x 10 mg
DMAB-anabaseine dihydrochloride
D-110 1 x 5 mg
I-110 1 x 250 mg
(-)-Nicotine ditartrate
N-175 1 x 1 g
PNU 282987
P-110 1 x 5 mg
RJR 2403 oxalate
R-115 1 x 5 mg
Varenicline tartrate
V-105 1 x 5 mg
  1. Kombo, D.C. et al. (2011) Eur. J. Med. Chem. 46, 5625.
  2. Albuquerque, E.X. et al (2009) Physiol. Rev. 89, 73.
  3. Kalamida, D. et al. (2007) FEBS J. 274, 3799.
  4. Karlin, A. et al. (1986) Ann. NY. Acad. Sci. 463, 53.
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