NaV1.8 Channel Basic Research Pack

All You Need for NaV1.8 Channel Research
  • Lyophilized Powder
  • Antigen Incl.
Cat #: ESB-003
Sizes: 5 Vials
Last update: 25/06/2019

Alomone Labs is pleased to offer the NaV1.8 Channel Basic Research Pack (#ESB-003). The Research Pack contains all you need for NaV1.8 research: Antibodies recognizing different domains of the channel and a NaV1.8 specific blocker, all in one economical package!

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Antibodies
Anti-NaV1.8 (SCN10A) Antibody
ASC-016 1 x 0.2 ml
Anti-NaV1.8 (SCN10A) (extracellular) Antibody
ASC-028 1 x 0.2 ml
Blockers/Antagonists
A-803467
A-105 1 x 50 mg
Scientific Background
    • Voltage-gated Na+ channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-1.9. 2-3 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels.4-5 Expression of the α subunit isoform is developmentally and tissue specific.

      Two TTX-resistant NaV channels are expressed in dorsal root ganglion (DRG) neurons, NaV1.8 and NaV1.9. The NaV1.8 channel (also called SNS, SCN10A and PN3) is mainly expressed in small-diameter DRG neurons.4-6 TTX-resistant channels have been suggested to play an important role in nociceptive transmission.

      Recently, involvement of NaV1.8 in multiple sclerosis (MS) was suggested due to up-regulation of both, mRNA and protein, in Purkinje cells of MS patients and also in animal models.6

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