NaV1.8 Channel Deluxe Research Pack

All You Need for NaV1.8 Channel Research
All You Need for NaV1.8 Channel Research
  • Lyophilized Powder
  • Antigen Incl.
  • Bioassay Tested
  • Shipped at Room Temp.
  • 100% Net Peptide
Cat #: ESD-003
Sizes: 11 Vials
Last update: 04/09/2018

Alomone Labs is pleased to offer the NaV1.8 Channel Deluxe Research Pack (#ESD-003). The Research Pack contains all you need for NaV1.8 research: Antibodies recognizing different domains of the channel and NaV1.8 blockers, all in one economical package!

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-NaV1.8 Antibody
ASC-016 1 x 0.2 ml
Anti-NaV1.8-ATTO-594 Antibody
ASC-016-AR 1 x 50 µl
Guinea pig Anti-NaV1.8 Antibody
AGP-029 1 x 0.2 ml
Anti-NaV1.8 (extracellular) Antibody
ASC-028 1 x 0.2 ml
A-803467
A-105 1 x 50 mg
Tolperisone hydrochloride
T-115 1 x 100 mg
VSTX3
STT-350 1 x 0.1 mg
Note A guinea pig polyclonal antibody (#AGP-029) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

Voltage-gated Na+ channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-1.9. 2-3 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels.4-5 Expression of the α subunit isoform is developmentally and tissue specific.

Two TTX-resistant NaV channels are expressed in dorsal root ganglion (DRG) neurons, NaV1.8 and NaV1.9. The NaV1.8 channel (also called SNS, SCN10A and PN3) is mainly expressed in small-diameter DRG neurons.4-6 TTX-resistant channels have been suggested to play an important role in nociceptive transmission.

Recently, involvement of NaV1.8 in multiple sclerosis (MS) was suggested due to up-regulation of both, mRNA and protein, in Purkinje cells of MS patients and also in animal models.6

References
  1. Lai, J. et al. (2003) Curr. Opin. Neurobiol. 13, 291.
  2. Renganathan, Met al. (2003) Brain Res959, 235.
  3. Fang, X. et al. (2002) J. Neurosci22, 7425.
  4. Wu, Let al. (2002) Neuro. Report 13, 2547.
  5. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27.
  6. Fjell, Jet al. (2000) Neuro. Report 11, 199.
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