Neurotensin

NTS, NTS1, NT
A Ligand of Neurotensin G-Protein Coupled Receptor
    Cat #: GPN-100
    Alternative Name NTS, NTS1, NT
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1689.99 Da.
    Purity: >98% (HPLC)
    Effective concentration 5-200 nM.
    Sequence ELYENKPRRPYIL.
    Modifications pyro-Glu1.
    Molecular formula C78H121N21O20.
    CAS No.: 55508-42-4.
    Activity Neurotensin is an endocrinic or paracrinic hormone. It plays a role in the regulation of fat metabolism, feeding suppression, circadian pacemaker, anti-psychotic-like action, body temperature, dopamine neurotransmission, and smooth muscle contraction and vasodilatation1,2.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to one week at 4°C or three months at -20°C.
      • Neurotensin
        Alomone Labs Neurotensin induces Ca2+ influx in HT29 cells.
        Cells were loaded with Fluo-3AM Ca2+ probe. Ca2+ influx was measured in the presence of increasing  Neurotensin (#GPN-100) concentrations. The maximum Ca2+ levels is plotted for each neurotensin concentration (ED50 = 142 ng/ml).
    References - Scientific background
      • Neurotensin is a peptide neurotransmitter hormone produced from a 170 amino acid precursor protein, first isolated in 1973 from bovine hypothalamus1. Neurotensin signaling is transmitted through three receptors, NTS1 and NTS2 are 7-transmembrane G-protein coupled receptors, and NTS3 is a type I membrane receptor with a large extra cellular domain2.

        Neurotensin synaptic transmission is terminated primarily by specific enzymatic cleavage of neurotensin by several peptidases3. Neurotensin participates in the regulation of Hypophyseal Prolactin and Luteinizing Hormone (LH) secretion4 and has a pivotal role in the dopaminergic system regulation.

        Neurotensin is implicated in body temperature regulation, feeding behavior, locomotion regulation5 and pain transmission6.

        GPCR ligands are now part of our growing portfolio of GPCR related products, which also includes antibodies.

    Target Neurotensin Receptors
    Net Peptide Content: 100%
    Last update: 06/11/2019

    Neurotensin (#GPN-100) is a highly pure, synthetic, and biologically active peptide.

    For research purposes only, not for human use
    Citations
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