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PLTX-II

ω-Plectoxin-Pt1a, ω-PLTX-Pt1a, PLTX-2

An Inhibitor of CaV Channels

Cat #: P-510
Alternative Name ω-Plectoxin-Pt1a, ω-PLTX-Pt1a, PLTX-2
Lyophilized Powder yes
Origin Natural peptide isolated from Plectreurys tristis (Spider).
MW: 5109 Da
Purity: >99% (HPLC)
Effective concentration 10-50 nM.
Sequence ADCSATGDTCDHTKKCCDDCYTCRCGTPWGANCRCDYYKARCDT.
Modifications Disulfide bonds between Cys3-Cys17, Cys10-Cys23, Cys16-Cys35, Cys20-Cys42 and Cys25-Cys33. Thr44 - C-terminal amidation and Opalmitoylation.
Structure
Molecular formula C208H312N60O71S10.
Activity PLTX-II is a voltage-gated Ca2+ channel blocker.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Water or 0.9% NaCl solution. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or three months at -20°C.
References - Scientific background
  1. Leung, H.T. et al. (1989) Neuron 3, 767.
  2. Branton, W.D. et al. (1993) Nature 365, 496.
  3. Gu, H. et al. (2009) J. Neurophysiol101, 42.
  4. Hou, J.  et al. (2008)  J. Neurophysiol100, 2833.
Scientific background Plectreurys toxin (PLTX-II) is a 44 amino acid peptidyl toxin produced by Plectreurys tristis spider1,2. PLTXII was found as a potent blocker of the CaV2 channel (CAC) that inactivates Ca2+ currents in pupal neurons3 and in antennal lobe PNs of adult Drosophila brain. PLTX-II regulates the miniature excitatory postsynaptic current frequency at excitatory cholinergic synapses of these neurons in vitro and in situ and acts as a presynaptic Ca2+-channel blocker3,4.
Target CaV Ca2+ channels
Net Peptide Content: 100%
Last update: 11/04/2021

PLTX-II (#P-510) is a highly pure, natural, and biologically active peptide toxin.

For research purposes only, not for human use

Applications

Specifications

Scientific Background

Citations

Citations
Product citations
  1. Ormerod, K.G. et al. (2013) J. Neurophysiol. 110, 1984.
  2. Chen, Z. et al. (2010) J. Neurosci. 30, 6247.
  3. Hartwig, C.L. et al. (2008) Dev. Neurobiol. 68, 1225.
  4. Worrell, J.W. and Levine, R.B. (2008) J. Neurophysiol. 100, 868.
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