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Certificate of Analysis

  • Bioassay Tested

SERCA Pump Inhibitor Explorer Kit

A Screening Package of SERCA Pump Inhibitors Economically Priced
Cat #: EK-365
Size: 6 Vials
Form: Lyophilized

Chelerythrine chloride Cat #: C-400

Size: 1 mg Source: Natural MW: 383.84 Purity: >99%
Origin
Macleaya Cordata.
Effective concentration
1-5 µM.
Activity
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C (PKC). It is at least 100-fold more selective for PKCs than for other kinases1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Water or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or six months at -20°C.

Cyclopiazonic Acid Cat #: C-750

Size: 5 mg Source: Natural MW: 336.4 Purity: >99% (HPLC)
Origin
Penicillium griseofulvum.
Effective concentration
1-10 µM.
Activity
Cyclopiazonic acid is a cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or three months at -20°C.

NS-1619 Cat #: N-105

Size: 5 mg Source: Synthetic MW: 362.2 Purity: >95%
Effective concentration
100 nM - 100 μM.
Activity
NS-1619 is a potent and selective KCa1.1 (BK, slo, Large conductance Ca2+-activated K+) channel modulator (enhancer)1. NS-1619 was effective in eliciting and enhancing KCa1.1 channels in smooth muscle as well as in neurons with maximal effects at concentrations around 30 μM1,2. NS-1619 was used in vivo by intracarotid infusion and significantly enhanced blood tumor barrier permeability in the brain tumor area but not in normal brain tissue3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Ochratoxin A Cat #: O-400

Size: 0.5 mg Source: Natural MW: 403.8 Purity: >98%
Origin
Aspergillus ochraceus.
Effective concentration
100 nM - 1 μM.
Activity
Ochratoxin A causes an increase in ATP-driven Ca2+ pump activity in the ER1. Ochratoxin A also induces apoptosis in a JNK-dependent fashion2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or three months at -20°C.
Protect from light.

Paxilline Cat #: P-450

Size: 0.45 mg Source: Natural MW: 435.6 Purity: >98% (HPLC)
Origin
Penicillium paxilli.
Effective concentration
10-100 nM.
Activity
Paxilline is a selective blocker of high-conductance Ca2+-activated (Maxi-K) K+ channels.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO or acetone. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or three months at -20°C.

Thapsigargin Cat #: T-650

Size: 0.65 mg Source: Natural MW: 650.7 Purity: >99% (HPLC)
Origin
Thapsia garganica.
Effective concentration
50 nM - 1 μM.
Activity
Thapsigargin is a highly potent inhibitor of the sarco-endoplasmic reticulum Ca2+-ATPases (SERCAs), inhibiting Ca2+ pumping to intracellular stores at nanomolar concentrations, with IC50 ranging from 0.2 nM to 50 nM in various mammalian cell types.1 Thapsigargin-induced depletion of Ca2+ stores leads to apoptosis in various cell lines.2-4
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO, ethanol or acetone. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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