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An Enhancer of NaV Currents

Cat #: P-170
Alternative Name α-PMTX
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1529 Da
    Purity: >98% (HPLC)
    Effective concentration 10-100 µM.
    Modifications Lys13 - C-terminal amidation.
    Molecular formula C71H123N19O18.
    Activity α-Pompilidotoxin slows NaV channel inactivation without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse1-3.
    1. Sahara, Y. et al. (2000) Eur. J. Neurosci. 12, 1961.
    2. Konno, K. et al. (2000) Neurosci. Lett. 285, 29.
    3. Konno, K. et al. (1998) Biochem. Biophys. Res. Commun250, 612.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to one week at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs α-Pompilidotoxin enhances native NaV currents in ND7-23 cells.
      Alomone Labs α-Pompilidotoxin enhances native Nacurrents in ND7-23 cells.
      The effect on inward currents of a bath application of 100 µM α-Pompilidotoxin (#P-170) (cyan). NaV currents were elicited every 15 sec from a holding potential of -100 mV, by 20 ms test pulses to -10 mV.
    References - Scientific background
    1. Sahara, Y. et al. (2000) Eur. J. Neurosci12, 1961.
    2. Konno, K. et al. (2000) Neurosci. Lett285, 29.
    3. Konno, K. et al. (1998) Biochem Biophys. Res. Commun250, 612.
    4. Harsch, A. et al. (1998) Neurosci. Lett252, 49.
    Scientific background

    α-PMTX was originally isolated from Anoplius samariensis and Batozonellus maclifrons wasps. This is a synthetic version of the peptide. α-PMTX induces a unique pattern of repetitive action potentials previous seen with other neurotoxins and thus facilitate both excitatory and inhibitory synaptic transmission.

    Recently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons.1-3 Effective at concentrations of 10 nM in cultured rat cortical neurons.4

    Target TTX-sensitive Nachannels
    Net Peptide Content: 100%
    Last update: 25/04/2021

    α-Pompilidotoxin (#P-170) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use



    Scientific Background


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