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ω-Conotoxin CVIB

A Blocker of N-, P/Q-Type Ca2+ Channels

Cat #: STC-410
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 2710 Da
    Purity: >98% (HPLC)
    Effective concentration 1-10 nM.
    Modifications Disulfide bonds between Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25. Cys25 - C-terminal amidation.
    Molecular formula C102H173N41O32S7.
    Activity ω-Conotoxin CVIB is a N-, P- and Q-type calcium channel blocker1.
    1. Lewis, R.J. et al. (2000) J. Biol. Chem. 275, 35335.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs ω-Conotoxin CVIB blocks CaV2.2 currents heterologously expressed in Xenopus oocytes.
      Alomone Labs ω-Conotoxin CVIB blocks CaV2.2 currents heterologously expressed in Xenopus oocytes.
      A. Time course of ω-Conotoxin CVIB (#STC-410) action on CaV2.2 maximum current amplitude. Current amplitudes were plotted as a function of time. Membrane potential was held at -100 mV and oocytes were stimulated by a 100 ms voltage ramp to +50 mV in 2 mM Ba2+. 10 nM ω-Conotoxin CVIB were perfused as indicated by the bar (green) for 5 min. B. Superimposed examples of CaV2.2 channel maximum peak current in the absence (control) and presence (green) of 10 nM ω-Conotoxin CVIB (taken from the experiment in A).
    References - Scientific background
    1. Lewis, R.J. et al. (2000) J. Biol. Chem. 275, 35335.
    Scientific background ω-Conotoxin CVIB is a peptide toxin originally isolated from the cat cone (Conus Catus). It is a blocker of voltage-gated N-,P- and Q-type CaV channels. CVIB has an effective concentration of 1-10 nM with an IC50 of 7.7 nM for N-type channels and 11 nM for P- and Q-type channels. Compared to other ω-conotoxins, CVIB is a fairly poor inhibitor of N-type channels and only a moderate inhibitor of P- and Q-type channels. Cloning and sequencing of mRNA transcripts from the venom ducts of the sea-snail failed to isolate CVIB’s mRNA transcript thus suggesting that this ω-conotoxin is not found abundantly in the Conus Catus species and may be found in other species of the cone snail family1.
    Target N-, P/Q-type Ca2+ channels
    Peptide Content: 100%
    Last update: 06/11/2022

    ω-Conotoxin CVIB (#STC-410) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use
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