Adrenergic Receptor Antibody Explorer Kit

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Adrenergic receptors (also called adrenoceptors) are the receptors for the catecholamines; adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions.

The adrenoceptors are members of the G-protein coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.

The adrenoceptors are divided into three types: α₁, α₂ and β adrenoceptors. Each type is further divided into at least three subtypes: α_1A, α_1B, α_1D, α_2A, α_2B, α_2C, β₁, β₂, β₃^1,2. They are expressed in nearly all peripheral tissues and in the central nervous system^1,2.