Lyophilized Powder This product is freeze dried. All water molecules have been removed.
Antigen Incl. This antibody is shipped with its antigen FREE of charge!
Shipped at Room Temp. This lyophilized product is shipped at room temperature. Please see its certificate of analysis for further storage instructions.
Alomone Labs is pleased to offer the Glutamate Transporter Antibody Explorer Kit (#AK-440). The Explorer Kit contains glutamate transporter antibodies, ideal for screening purposes.
| Product Name | Cat # | Size |
|---|---|---|
Anti-EAAT1 (extracellular) Antibody | AGC-021 | 1 x 50 µl |
Anti-EAAT2 (extracellular) Antibody | AGC-022 | 1 x 50 µl |
Anti-EAAT3 Antibody | AGC-023 | 1 x 50 µl |
Anti-EAAT4 (extracellular) Antibody | AGC-024 | 1 x 50 µl |
Anti-SLC1A7 (extracellular) Antibody | AGC-025 | 1 x 50 µl |
Anti-VGLUT1 Antibody | AGC-035 | 1 x 50 µl |
Anti-VGLUT2 Antibody | AGC-036 | 1 x 50 µl |
Anti-VGLUT3 Antibody | AGC-037 | 1 x 50 µl |
The transport of Glu into the cells by the EAAT transporters is coupled to the Na+ and K+ electrochemical gradient as a driving force. Hence, the uptake of Glu is dependent on the co-transport of three Na+ and one H+ ions, and the counter transport of one K+ ion.
In addition, to the well documented Glu uptake, the EAAT transporters show a Glu-independent Cl- conductance. The physiological significance of the Cl- current through the EAATs is currently unknown.1,2
EAAT1 as well as EAAT2, is expressed predominantly in glia cells (hence its original name: glial glutamate transporter or GLAST), while EAAT3, EAAT4 and EAAT5 are mostly expressed in neurons.
Three vesicular glutamate transporters (VGLUTs) have been cloned: BNPI/VGLUT1 (a brain-specific sodium dependent inorganic phosphate (Pi) transporter), and its homologs DNPI/VGLUT2 (differentiation-associated sodium-dependent Pi transporter) and VGLUT33. These transporters mediate glutamate uptake inside presynaptic vesicles and are anatomical and functional markers of glutamatergic excitatory transmission4.
