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Glutamate Transporter Antibody Explorer Kit

A Screening Package of Glutamate Transporter Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-440
Sizes: 16 Vials
Last update: 24/04/2019

Alomone Labs is pleased to offer the Glutamate Transporter Antibody Explorer Kit (#AK-440). The Explorer Kit contains glutamate transporter antibodies, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Anti-EAAT1 (GLAST) (extracellular) Antibody
 		AGC-021 1 x 50 µl
Anti-EAAT2 (GLT-1) (extracellular) Antibody
 		AGC-022 1 x 50 µl
Anti-EAAT3 (EAAC1) Antibody
 		AGC-023 1 x 50 µl
Anti-EAAT4 (extracellular) Antibody
 		AGC-024 1 x 50 µl
Anti-SLC1A7 (extracellular) Antibody
 		AGC-025 1 x 50 µl
Anti-VGLUT1 Antibody
 		AGC-035 1 x 50 µl
Anti-VGLUT2 Antibody
 		AGC-036 1 x 50 µl
Anti-VGLUT3 Antibody
 		AGC-037 1 x 50 µl
Scientific Background

    • The transport of Glu into the cells by the EAAT transporters is coupled to the Na+ and K+ electrochemical gradient as a driving force. Hence, the uptake of Glu is dependent on the co-transport of three Na+ and one H+ ions, and the counter transport of one K+ ion.  

      In addition, to the well documented Glu uptake, the EAAT transporters show a Glu-independent Cl- conductance. The physiological significance of the Cl- current through the EAATs is currently unknown.1,2

      EAAT1 as well as EAAT2, is expressed predominantly in glia cells (hence its original name: glial glutamate transporter or GLAST), while EAAT3, EAAT4 and EAAT5 are mostly expressed in neurons.

      Three vesicular glutamate transporters (VGLUTs) have been cloned: BNPI/VGLUT1 (a brain-specific sodium dependent inorganic phosphate (Pi) transporter), and its homologs DNPI/VGLUT2 (differentiation-associated sodium-dependent Pi transporter) and VGLUT33. These transporters mediate glutamate uptake inside presynaptic vesicles and are anatomical and functional markers of glutamatergic excitatory transmission4.
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