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Glutamate Transporter Antibody Explorer Kit

A Screening Package of Glutamate Transporter Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
  • Shipped at Room Temp.
Cat #: AK-440
Sizes: 16 Vials
Last update: 03/09/2018

Alomone Labs is pleased to offer the Glutamate Transporter Antibody Explorer Kit (#AK-440). The Explorer Kit contains glutamate transporter antibodies, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-EAAT1 (GLAST) (extracellular) Antibody
 AGC-021 1 x 50 µl
Anti-EAAT2 (GLT-1) (extracellular) Antibody
 AGC-022 1 x 50 µl
Anti-EAAT3 Antibody
 AGC-023 1 x 50 µl
Anti-EAAT4 (extracellular) Antibody
 AGC-024 1 x 50 µl
Anti-SLC1A7 (extracellular) Antibody
 AGC-025 1 x 50 µl
Anti-VGLUT1 Antibody
 AGC-035 1 x 50 µl
Anti-VGLUT2 Antibody
 AGC-036 1 x 50 µl
Anti-VGLUT3 Antibody
 AGC-037 1 x 50 µl
Scientific Background
Scientific Background

The transport of Glu into the cells by the EAAT transporters is coupled to the Na+ and K+ electrochemical gradient as a driving force. Hence, the uptake of Glu is dependent on the co-transport of three Na+ and one H+ ions, and the counter transport of one K+ ion.  

In addition, to the well documented Glu uptake, the EAAT transporters show a Glu-independent Cl- conductance. The physiological significance of the Cl- current through the EAATs is currently unknown.1,2

EAAT1 as well as EAAT2, is expressed predominantly in glia cells (hence its original name: glial glutamate transporter or GLAST), while EAAT3, EAAT4 and EAAT5 are mostly expressed in neurons.

Three vesicular glutamate transporters (VGLUTs) have been cloned: BNPI/VGLUT1 (a brain-specific sodium dependent inorganic phosphate (Pi) transporter), and its homologs DNPI/VGLUT2 (differentiation-associated sodium-dependent Pi transporter) and VGLUT33. These transporters mediate glutamate uptake inside presynaptic vesicles and are anatomical and functional markers of glutamatergic excitatory transmission4.

References
  1. Tzingounis, A.V. and Wadiche, J.I. (2007) Nat. Rev. Neurosci. 8, 935.
  2. Beart, P.M. and O’Shea, R.D. (2007) Br. J. Pharmacol. 150, 5.
  3. Gong, J. et al. (2006) Brain Res. 1082, 73.
  4. Fremeau, R.T. et al. (2004) Science 304, 1815.
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