GIRK (Kir3) Channel Antibody Explorer Kit

A Screening Package of GIRK (Kir3) Channel Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-227
Sizes: 9 Vials
Last update: 28/03/2019

Alomone Labs is pleased to offer the GIRK (Kir3) Channel Antibody Explorer Kit (#AK-227). This Explorer Kit includes antibodies targeting GIRK (Kir3) channels along with their respective peptide control antigen (where applicable). An ideal tool for screening purposes.

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Anti-GIRK1 (Kir3.1) Antibody
APC-005 1 x 50 µl
Mouse Anti-GIRK1 (Kir3.1) (extracellular) Antibody
ALM-031 1 x 25 µg
Anti-GIRK2 (Kir3.2) Antibody
APC-006 1 x 50 µl
Anti-GIRK3 (Kir3.3) Antibody
APC-038 1 x 50 µl
Anti-KCNJ5 (Kir3.4) Antibody
APC-027 1 x 50 µl
Note A mouse monoclonal antibody (#ALM-031) is included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels, the functional unit for the Kir channels is composed of four subunits that can assemble as either homo or heterotetramers.

Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis.

Kir3.1 is a member of the Kir3.x subfamily that includes four members (Kir3.1- Kir3.4). The Kir3 (GIRK) family is characterized by the fact that the channels can be activated by neurotransmitters and other factors acting via the activation of G-protein coupled receptors. Binding of the corresponding ligand to the G-protein receptor induces the dissociation of Gα-GTP from the Gβγ dimer. The latter directly binds to Kir3 and activates the channel1,2.

References
  1. Dascal, N. (1997) Cell Signal 9, 551.
  2. Mark, M.D. et al. (2000) Eur. J. Biochem. 267, 5830.
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