Alomone Labs is pleased to offer the GIRK (Kir3) Channel Antibody Explorer Kit (#AK-227). This Explorer Kit includes antibodies targeting GIRK (Kir3) channels along with their respective peptide control antigen (where applicable). An ideal tool for screening purposes.
|Product Name||Cat #||Size|
|APC-005||1 x 50 µl|
|ALM-031||1 x 25 µg|
|APC-006||1 x 50 µl|
|APC-038||1 x 50 µl|
|APC-027||1 x 50 µl|
The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels, the functional unit for the Kir channels is composed of four subunits that can assemble as either homo or heterotetramers.
Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis.
Kir3.1 is a member of the Kir3.x subfamily that includes four members (Kir3.1- Kir3.4). The Kir3 (GIRK) family is characterized by the fact that the channels can be activated by neurotransmitters and other factors acting via the activation of G-protein coupled receptors. Binding of the corresponding ligand to the G-protein receptor induces the dissociation of Gα-GTP from the Gβγ dimer. The latter directly binds to Kir3 and activates the channel1,2.
- Tertiapin (#STT-250)
- Tertiapin-LQ (#STT-220)
- Tertiapin-Q (#STT-170)
- Tertiapin-Q-ATTO Fluor-488 (#STT-170-AG)
- Tertiapin-Q-ATTO Fluor-633 (#STT-170-FR)
- Guinea pig Anti-GIRK2 (Kir3.2) Antibody (#AGP-013)
- GIRK2 (Kir3.2) Channel Overexpressed Membrane Fractions (#LX-102)
- Cardiac Kir Channel Antibody Explorer Kit (#AK-330)
- Kir Channel Antibody Explorer Kit (#AK-200)
- Kir Channel Blocker Explorer Kit (#EK-112)