Name: MCI-225
Brand: Alomone Labs
SKU: M-190
Availability: InStock

Cat #: M-190

Alternative Name DDP-225

Lyophilized Powder yes

Bioassay Tested

Source Synthetic

MW: 328.4

Purity: >98%

Effective concentration 10 nM - 1 µM.

Structure

Chemical name 4-(2-fluorophenyl)-6-methyl-2-piperazin-1-ylthieno[2,3-d]pyrimidine.

Molecular formula C₁₇H₁₇FN₄S.

CAS No.: 135991-48-9

PubChem CID 131927

Activity MCI-225 shows high affinity for the 5-HT3 receptor, K_i less than 100 nmol/L¹.

References-Activity

Eguchi, J. et al. (2001) Pharmacol. Biochem. Behav. 68, 677.

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Solubility 30 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions Up to four weeks at 4°C or three months at -20°C.

Our bioassay

Alomone Labs MCI-225 blocks 5-HT3A receptors expressed in HEK 293T cells.
5-HT3A receptor currents were elicited by 10 µM 5-HT, delivered every 3 minutes. MCI-225 (#M-190) was applied 30 seconds before stimulation at 10 and 100 nM, as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.

Scientific background

MCI-225 is a psychoactive compound, a thienopyrimidine analogue that acts as a selective noradrenaline (NA) reuptake inhibitor with 5-HT3 channel blocking action. The compound demonstrates antidepressant-like activity with primary activity in the central nervous system.

Several studies have shown that MCI-225 exhibits improvement in amnesia in scopolamine treated rats and in basal forebrain lesion rats. Acute administration of MCI-225 inhibits the rise of threshold induced by footshock stress¹.

It has been suggested that MCI-225 may affect attention, learning and memory².

Target 5-HT3A receptor, NET transporter

Lyophilized Powder

Last update: 11/04/2021

For research purposes only, not for human use

Specifications

Applications

Scientific Background

Citations

Shipping and Ordering information

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Certificate of Analysis

MCI-225

Specifications

Applications

Scientific Background

Citations

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