Every lot is tried & tested in a relevant biological assay.
Our Bioassay
- Edwards, G. et al. (1994) Br. J. Pharmacol. 113, 1538.
- Sellers, A.G. and Ashford, L.M.J. (1994) Br. J. Pharmacol. 113, 659.
- Ningaraj, N.S. et al. (2002) J. Pharmacol. Exp. Ther. 301, 838.
- Alomone Labs NS-1619 enhances KCa1.1 currents in Xenopus oocytes.A. Families of KCa1.1 channel current responses to increasing voltage step stimulation (from -50 mV to + 50 mV), before (left) and during (right) application of 100 μM NS-1619 (#N-105). Currents were elicited by 100 ms voltage step from -100 mV applied every 10 sec. B. Time course of current amplitude at 0 mV before, during application of 100 μM NS-1619 (green) and upon wash, demonstrating the current amplitude enhancement. C. Voltage dependence of KCa1.1 channel activity enhancement.
- Andersson K.E. et al. (2004) Physiol. Rev. 84, 935.
- Heppner, T.J. et al. (1997) Am. J. Physiol. 273, C110.
- Salkoff, L. et al. (2006) Nat. Rev. Neurosci. 7, 921.
- Olesen S.P. et al. (1994) Eur. J. Pharmacol. 251, 53.
- Holland M. et al. (1996) Br. J. Pharmacol. 117, 119.
- Macmillan S. et al. (1995) Br. J. Pharmacol. 116, 1656.
- Yamamura H. et al. (2001) Br. J. Pharmacol. 132, 828.
- Han X. et al. (2008) Biochem. Biophys. Res. Commun. 375, 205.
- Wrzosek, A. (2014) Cell Calcium 56, 14.
The large conductance voltage- and Ca2+-activated K+ (BK) channels, also known as BKCa, KCa1.1, Slo, or MaxiK, play an important role in modulating nerve and muscle cell contractility and excitability1-3. BK channels are activated by both depolarizing voltages and by an increase in intracellular free Ca2+, thus coupling the membrane potential to intracellular signaling.
NS-1619 is a potent and selective KCa1.1 channel modulator (enhancer)4. It has the potential to modulate cell excitability in neurons and smooth muscle5-7. The effect of relaxation of NS-1619 on the BK channel in smooth muscle cells has an EC50 of 10–30 µM. It is also dose-dependent, resulting in a shift of the activation curve by up to -50 mV towards negative membrane potentials, but fully reversible8.
NS-1619 also modulates intracellular Ca2+ by inhibiting SERCA pumps9.
NS-1619 (#N-105) is a highly pure, synthetic, and biologically active compound.
Applications
Citations
Specifications
Scientific Background
Related Products
Need Help With This Product?
Our reagent specialists are here to help you find the best product for your application. Please call or email us and we will be happy to help you find the right product for the job.
Call us at
+972 2587 2202 or Email Us