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(RS)-(Tetrazol-5-yl)glycine

Tet-glycine, Tetrazolylglycine, Tetrazol-5-yl-gly, 5-Tetrazolyl-glycine, LY 285 265
A Potent NMDA Receptor Agonist
Cat #: T-205
Alternative Name Tet-glycine, Tetrazolylglycine, Tetrazol-5-yl-gly, 5-Tetrazolyl-glycine, LY 285 265
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 143.1
    Purity: >98%
    Effective concentration 0.1-25 µM.
    Structure
    Chemical name 2-amino-2-(2H-tetrazol-5-yl)acetic acid.
    Molecular formula C3H5N5O2.
    CAS No.: 138199-51-6.
    PubChem CID 126383
    Activity (RS)-(Tetrazol-5-yl)glycine is a highly potent and selective NMDA receptor agonist (significantly more potent than NMDA or glutamate), inhibiting [3H]glutamate binding to rat brain NMDA receptors with IC50 of 36 nM1. in vitro, it activates NR1/NR2A NMDA receptors with EC50 of 1.77 µM2.
    References-Activity
    1. Schoepp, D.D. et al. (1991) Eur. J. Pharmacol. 203, 237.
    2. Chen, P.E. et al. (2005) Mol. Pharmacol. 67, 1470.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble up to 25 mM in water, with gentle heating. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Store at -20°C. It is recommended to prepare fresh solutions before use, or aliquot stock solutions stored at -20°C. Prevent repeated thawing.
    Our bioassay
    • Alomone Labs (RS)-(Tetrazol-5-yl)glycine activates NMDA receptors expressed in Xenopus oocytes.
      Alomone Labs (RS)-(Tetrazol-5-yl)glycine activates NMDA receptors expressed in Xenopus oocytes.
      A. Representative time course of NR1/NR2A current activation by 3.5 min applications of 0.4 μM, 2 μM and 10 μM (RS)-(Tetrazol-5-yl)glycine (#T-205), as indicated, in the presence of 50 μM glycine (top dotted line), at membrane holding potential of -60 mV. B.Representative current traces of NR1/NR2A, elicited by transient stimulations with control and with 10 µM and 25 µM (RS)-(Tetrazol-5-yl)glycine (as indicated), in the presence of 10 μM glycine, while membrane potential was held at -60 mV.
    References - Scientific background
    1. Schoepp, D.D. et al. (1991) Eur. J. Pharmacol. 203, 237.
    2. Black, S.A. et al. (2014) Front. Cell Dev. Biol. 2, 45.
    3. Chen, P.E. et al. (2005) Mol. Pharmacol. 67, 1470.
    Scientific background

    (RS)-(Tetrazol-5-yl)glycine is a synthetic compound that acts as highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist. The compound is significantly more potent than NMDA or glutamate. When given to neonatal rats, (RS)-(Tetrazol-5-yl) glycine was found to be highly potent convulsant1.

    NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction, and stroke. They also mediate physiological functions such as learning and memory formation and participate in glutamate excitotoxicity2.

    (RS)-(Tetrazol-5-yl)glycine inhibits [3H]glutamate binding to rat brain NMDA receptors with an IC50 value of 36 nM1. in vitro studies show that (RS)-(Tetrazol-5-yl)glycine can activate NR1/NR2A NMDA receptors with an EC50 value of 1.77 µM3.

    Target NMDA receptors
    Last update: 23/08/2020

    (RS)-(Tetrazol-5-yl)glycine (#T-205) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
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